Tripotassium citrate

HCID 13344CAS 7778-49-6

Grundinformationen

Standard-SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+]
InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K
Summenformel
C6H5K3O7
Durchschnittliche Molmasse
306,39 g/mol
Monoisotopische Masse
305,8946469

Namen und Bezeichner

Bevorzugter Name
Tripotassium citrate
IUPAC
tripotassium;2-hydroxypropane-1,2,3-tricarboxylate

Namen und Synonyme

TRIPOTASSIUM CITRATE866-84-2KaliksirPotassium citrate anhydrousLitocitPorekalKajosUrocit KSeltz-KK citrateCitric acid, tripotassium saltPotassium tribasic citrate
Weitere Namen anzeigen
ACALKA86R1NVR0HW1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium saltDTXSID8027325RefChem:933490Anhydrous, Potassium CitrateDTXCID907325212-755-5

Datenbank-Bezeichner

CAS
7778-49-6、866-84-2
PubChem CID
13344
DTXSID
DTXSID8027325
ChEMBL
CHEMBL1200458
ChEBI
CHEBI:64733
UNII
86R1NVR0HW
EC Number
212-755-5、231-905-0
Nikkaji
J7.148J

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
141 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
7
Frei drehbare Bindungen
2
Schwere Atome
16

Experimentelle und physikochemische Eigenschaften

pH · 2 Einträge

Between 7,5 and 9,0 (5 % aqueous solution)

THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5

OdorODORLESS
TasteHAS COOLING, SALINE TASTE
Density1.98 @25 °C
Color/Form · 2 Einträge

WHITE CRYSTALS, GRANULES, OR POWDER

TRANSPARENT CRYSTALS

Solubility · 3 Einträge

1 G DISSOLVES IN 0.65 ML WATER

1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL

ALMOST INSOL IN ALCOHOL

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 572 of 594 companies (only 3.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 572 of 594 reports by companies.;There are 2 notifications provided by 22 of 594 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 14 of 14 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 14 of 14 reports by companies.;There are 0 notifications provided by 0 of 14 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 5 Einträge

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment
Hazards SummaryPotassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]
FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.
EPA Safer ChemicalChemical: Potassium citrate, anhydrous; Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
Hazard Classes and Categories · 2 Einträge

Not Classified

Not Classified

Sicherheit und Schutzausrüstung

Protective Action Criteria (PAC) · 3 Einträge

2.1 [mg/m3]

23 [mg/m3]

140 [mg/m3]

Toxikologische Informationen

Interactions12 OF 40 HEART PT TREATED WITH POTASSIUM CITRATE SHOWED SLIGHT MALABSORPTION OF VITAMIN B12. MECHANISM OF THE DISTURBANCE APPEARED TO BE ACIDIFICATION OF CONTENTS OF THE ILEUM.
Human Toxicity ExcerptsCONGENITAL MALFORMATIONS AND SURVIVAL IN RELATION TO THE FIRST TRIMESTER USE OF SPECIFIC DRUGS AND VACCINES ARE PRESENTED.

Regulatorische Informationen

Regulatory Information · 5 Einträge

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 5 Einträge

86R1NVR0HW

POTASSIUM CITRATE ANHYDROUS

Mechanisms of Action [MoA] - Alkalinizing Activity

Established Pharmacologic Class [EPC] - Metabolic Alkalinizer

Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.

MeSH Pharmacological Classification · 2 Einträge

Agents that promote the excretion of urine through their effects on kidney function.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

Verwendung und Herstellung

Uses · 6 Einträge

Used as a food additive (sequestrant, stabilizer, and buffer), a preservative for cut flowers, and a medication (potassium supplement, diuretic, expectorant, and alkalizer); [HSDB] Used as chemical intermediate; [MSDSonline]

MEDICATION

MEDICATION (VET)

SEQUESTRANT FOOD ADDITIVE

STABILIZER, BUFFER IN FOODS

IN PRESERVATION OF CUT FLOWERS

U.S. Production · 2 Einträge

2023: 75,000 - <100,000 lb;2022: 75,000 - <100,000 lb;2021: 75,000 - <100,000 lb;2020: 50,000 - <250,000 lb

2023: 1,000,000 - <2,500,000 lb;2022: 2,500,000 - <4,000,000 lb;2021: 2,500,000 - <4,000,000 lb;2020: 1,000,000 - <2,500,000 lb

Consumer UsesSoil amendments (fertilizers);Emulsifier
Industry UsespH regulating agent;Soil amendments (fertilizers);Emulsifier
Methods of ManufacturingBY ADDING POTASSIUM BICARBONATE OR CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, FILTERING THE SOLN & EVAPORATION TO GRANULATION.
Formulations/Preparations · 3 Einträge

POTASSIUM CITRATE, NF. POWDER, NF. TABLETS, 2.3 MEQ OF K+ AND 0.8 MEQ OF C6H5O7(3-) (250 MG), 2.8 MEQ OF K+ AND 0.9 MEQ OF C6H5O7(3-) (300 MG), AND 5.6 MEQ OF K+ AND 1.8 MEQ OF C6H5O7(3-) (600 MG).

IT IS AT LEAST 99% PURE.

GRADES: TECHNICAL; CP; NF; FCC.

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