Citric Acid → Trisodium citrate

HRID 420013

Reaktionsgleichung

Reaktionsgleichung von HRID 420013
[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[C:22]([OH:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([OH:32])=[O:31])([C:26]([OH:28])=[O:27])[OH:25].C(=O)([O-])[O-].[K+:39].[K+].O.C(=O)(O)[O-].[Na+:46]>>[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[C:22]([O-:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([O-:32])=[O:31])([C:26]([O-:28])=[O:27])[OH:25].[Na+:46].[Na+:46].[Na+:46].[C:22]([O-:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([O-:32])=[O:31])([C:26]([O-:28])=[O:27])[OH:25].[K+:39].[K+:39].[K+:39]

Komponenten

8

Edukt 5

HCID 311Citric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 60835Duloxetine3×HCID 516892Sodium Bicarbonate

Produkt 3

HCID 6224Trisodium citrateHCID 13344Tripotassium citrateHCID 60835Duloxetine

Versuchsvorschrift

Effervescent Tablets and Granules were prepared using standards techniques known to persons skilled in the art. For Example: From one 20 mg duloxetine capsule, granules were emptied into mortar and pestle to prepare fine powder. A homogeneous mixture of effervescent duloxetine powder was obtained by diluting the above powdered duloxetine with about 958 mg sodium bicarbonate USP, about 832 mg citric acid USP and about 312 mg potassium carbonate USP. This powder reacted with the 60 ml water to create effervescence resulting in a bubbling solution of duloxetine with sodium citrate and potassium citrate as principal antacids

Aufarbeitung

  1. customEffervescent Tablets and Granules were prepared
  2. customto prepare fine powder
  3. customwas obtained

Quellen und Nachweise

ORD-Eintrag
ord-3fe1b42f4dd541bba16678b948a2ee70
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093408B2

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