Zinc Carbonate

Cosmetic ingredients (Zinc Carbonate) -> CIR (Cosmetic Ingredient Review)

Opacifying

4.398 at 68 °F (USCG, 1999) - Denser than water; will sink

4.4 g/cu cm

4.4 @25 °C

WHITE RHOMBIC CRYSTALS

WHITE, CRYSTALLINE POWDER

RHOMBOHEDRAL STRUCTURE

0.001 G/100 G OF WATER AT 15 °C; SOL IN DIL ACIDS, ALKALIES & SOLN OF AMMONIUM SALTS.

INSOL IN AMMONIA, PYRIDINE & ACETONE

Insol in alcohol

Zinc carbonate appears as a white crystalline solid or powder that is insoluble in water. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used in pharmaceuticals, to make other zinc compounds, as a feed additive.

Dry Powder

White solid; [Hawley] White odorless powder; [MSDSonline]

This chemical does not meet GHS hazard criteria for 20.1% (74 of 369) of reports.

Warning

H400 (72.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P273, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 369 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Carbonic acid, zinc salt (1:1)

Carbonic acid, zinc salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Carbonic acid, zinc salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 29-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25398

Carbonic acid, zinc salt (1:1): Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations, January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.

USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079

USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003

Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.

For more Special Reports (Complete) data for ZINC CARBONATE (6 total), please visit the HSDB record page.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc & cmpd/

Designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

7.7 [mg/m3]

84 [mg/m3]

510 [mg/m3]

The effects of Eimeria acervulina infection (duodenal coccidiosis) on cadmium toxicity and zinc status in the young chick /were evaluated/. Additions of cadmium (45 mg/kg) were made to diets that contained either 0 or 52 mg/kg supplemental zinc (from zinc carbonate). Growth and efficiency of feed utilization were reduced by dietary cadmium addition while concurrent coccidial infection reduced these parameters further. Addition of cadmium also increased cadmium content of liver and kidney and depressed hemoglobin, hematocrit, and plasma zinc content. Coccidial infection exacerbated tissue cadmium deposition and depressed hematological parameters further. Although dietary zinc addition ameliorated some of the adverse effects of cadmium toxicity, cadium administration tended to enhance tissue zinc deposition.

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Carbonate...

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

INTAKES OF ZINC IN FORM OF ... CARBONATE, EQUAL TO 2500 PPM OF THE DIET, ARE COMPLETELY WITHOUT EFFECT ON RATS ... .

Female weanling C57BL/6J mice of 21 days of age were fed a diet containing normal (50 ppm) or excess (2000 ppm) levels of zinc administered as zinc carbonate. At about 6 weeks of age, treated females were bred with C57BL/6J males. Offspring were weaned and fed their mothers' diet until sacrifice at 8 weeks of age. Mice exposed to excess zinc during gestation/lactation/postweaning development had reduced plasma copper levels, lower hematocrit values, and reduced body weights, compared to controls. Mice exposed to excess dietary zinc began to lose hair at about 2-4 weeks of age, and at 5 weeks of age, the alopecia was most severe. The skin of treated mice at 5 weeks of age was thinner than that of controls. Hair regrowth began at about 6 weeks of age and the coat of hair had regrown by 8 weeks of age, but was lighter in color than that of control mice.

EXCESS ZINC CARBONATE RETARDS GROWTH IN WEANLING RATS, WHICH PRODUCE STILLBORN PUPS WHEN THEY MATURE. ... DIETARY ZINC CARBONATE REDUCED LIVER CYTOCHROME OXIDASE & CATALASE ACTIVITIES WHEN ZINC CONTENT WAS 0.4%.

The water insoluble salt, zinc carbonate, was not toxic to fish. Apparently, zinc toxicity to fish is influenced by temperature, pH, and salt solubility.

Even when they were fed zinc carbonate at a dietary level of 7000 ppm of zinc (350 mg/kg/day), young rats survived, although they developed marked anemia in 4 weeks and grew poorly. A dietary level of 10,000 ppm killed up to 75% of rats in 3-5 weeks.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc & cmpd/

Designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance.

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

ZINCUM CARBONICUM

Copper Absorption Inhibitor [EPC]; Decreased Copper Ion Absorption [PE]

The effects of different amounts of dietary zinc on the zinc absorption rate and on zinc, calcium and magnesium concn in tissues of MOPC104E tumor bearing Balb/c female mice were determined. Three groups of 7 mice each (each mouse inoculated with approx 1.25 million MOPC104E cells) were given one of three experimental diets containing adequate amounts of zinc (40 ug zinc/g), a zinc deficient diet (1.0 ug zinc/g), or a zinc excess diet (1 mg zinc/g). A group of 7 nontumor bearing mice was fed laboratory mice chow as a control. The zinc deficient diet contained 37.5 ug zinc/g. For the zinc adequate diet, 71.0 mg zinc carbonate/kg diet was added to the zinc deficient diet. For the zinc excess diet 1917.9 mg zinc carbonate/kg diet was added. After 14 days on the special diets, mice were given an intragastric dose of a 200 ul solution containing 0.37 MBq (65)zinc (specific activity: 37 MBq/mg). (65)Zn was determined in various organs by gamma counting. Another set of 28 mice were placed in the same experimental conditions as described above. After anesthesia with nembutal injection, each organ was analyzed for concn of zinc, calcium, and magnesium by atomic absorption spectrophotometry. The zinc absorption rate was inversely related to the amounts of zinc in the diet and was lower than that of nontumor bearing control mice fed a laboratory mice chow. Zinc concn of tumor bearing mice were also low compared with control mice but tumor zinc concn, regardless of the concn of zinc in the diets, were higher than those of normal tissues of the host other than the pancreas.

CIR ingredient: Zinc Carbonate

Found in the minerals smithsonite and zincspar; [Merck Index] Used in rubber and plastic products (fire-proofing filler), cosmetics and lotions, pigments, porcelain and pottery, astringents and topical antiseptics, and animal feeds; [HSDB] Used as a sulfide scavenger in muds and to make drugs (ointments and dusting powders); [CHEMINFO]

Petroleum Production and Refining [Category: Industry]

Ceramics making [Category: Hobbies]

AS FIRE-PROOFING FILLER FOR RUBBER & PLASTIC COMPOSITIONS EXPOSED TO FLAME TEMPERATURE; IN COSMETICS & LOTIONS; MFR ZINC SALTS; AS FEED ADDITIVE, TOPICAL ANTISEPTIC.

AS PIGMENT; MFR OF PORCELAINS, POTTERY, RUBBER.

Soap, Cleaning Compound, and Toilet Preparation Manufacturing

Carbonic acid, zinc salt (1:1): ACTIVE