Sodium Trimetaphosphate

Cosmetic ingredients (Sodium Trimetaphosphate) -> CIR (Cosmetic Ingredient Review)

Anticaking; Chelating; Buffering

Dry Powder; Other Solid

Hexahydrate: Efflorescent solid; [Merck Index] White odorless powder; [MSDSonline]

Loses water on storage at 20 °C, becomes definitely anhydrous at 100 °C. /Hexahydrate/

Efflorescent, triclinic-rhombohedral prisms. Melting point 53 °C. Specific gravity 1.786. One gram dissolves in 4.5 ml water. Insol in alc. /Hexahydrate/

This chemical does not meet GHS hazard criteria for 100% (132 of 132) of all reports.

Not Classified

Aggregated GHS information provided per 132 reports by companies from 1 notifications to the ECHA C&L Inventory.

Chemical: Metaphosphoric acid (H3P3O9), trisodium salt

Metaphosphoric acid (H3P3O9), sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Metaphosphoric acid (H3P3O9), sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-03-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/5327

Metaphosphoric acid (H3P3O9), trisodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Emergency treatment: Inorganic phosphates; Inorganic phosphates can cause diarrhea, hyperphosphatemia, and hypocalcemia after ingestion; An adult died after receiving four sodium phosphate enemas within 24 hours; he had electrolyte abnormalities and died from cardiac arrest; [HSDB] Oral LD50 (mouse) = 10300 mg/kg; [RTECS] May cause irritation; [MSDSonline]

Conditions of use: This substance is generally recognized as safe when used in accordance with good manufacturing practice.

Sodium metaphosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 454 kg. The toll free telephone number of the NRC is (800) 424-8802; In the Washington metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.6 (section IV. D.3.b).

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

If material /sodium phosphate, tribasic/ is involved in a fire: extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty). Keep material out of water sources and sewers, building dikes to contain flow as necessary.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Sodium Trimetaphosphate...

Safe for use in cosmetics, with qualifications

IDENTIFICATION AND USE: Trisodium trimetaphosphate exists as colorless efflorescent triclinic rhombohedral prisms. It is used in tooth polishing agents and used in synthetic dairy products. It is used in detergent processing, water softeners, sequesterants, emulsifiers, food additives, textile processing, and laundering. HUMAN EXPOSURE AND TOXICITY: Disodium salts such as the metaphosphates are toxic because of their excess alkalinity rather than from sodium excess. ANIMAL STUDIES: Rats fed diets containing this chemical, high doses had adverse effects on kidneys. Growth retardation was also observed in rats fed this chemical in diets.

/IN RAT/ DIETS CONTAINING 0.2, 2.0, & 10% SODIUM TRIMETAPHOSPHATE ... ONLY THE HIGHEST LEVELS WERE FOUND TO HAVE ADVERSE EFFECTS ON KIDNEYS; NONE OF THE LOWER LEVELS HAD ANY ADVERSE EFFECTS. ... A FURTHER STUDY OF 100 RATS FED DIETS CONTAINING 0.1, 1.0, & 10% SODIUM TRIMETAPHOSPHATE RESULTED IN RETARDED GROWTH FOR ALL RATS WHEN THE DIETS CONTAINED 10% & A REDUCTION IN GROWTH RATE FOR THOSE MALE RATS RECEIVING 1%.

EXPTL USE: THE LEVEL OF CARIES WAS LOWER IN RATS FED CARIES-CONDUCIVE DIETS CONTAINING 0.5 OR 1% TRIMETAPHOSPHATE THAN IN CONTROLS FED THE DIET ALONE, REGARDLESS OF WHETHER THE TRIMETAPHOSPHATE WAS FED IN THE DIET CONTINUOUSLY OR DURING ALTERNATING 24 HR PERIODS.

EXPTL USE: SODIUM METAPHOSPHATE INHIBITED EXPTL CALCULI FORMATION IN RAT BLADDER IN VIVO. THIS INHIBITORY EFFECT WAS DUE TO INCREASED URINARY EXCRETION OF PYROPHOSPHATES & PHOSPHORYLATED POLYPEPTIDES, WITH THEIR SUBSEQUENT CRYSTAL POISONING EFFECT.

EXPTL USE: THE INCLUSION OF SODIUM TRIMETAPHOSPHATE IN A HIGH-SUCROSE DIET DECREASED IN THE LEVAN HYDROLASE ACTIVITY OF PLAQUE, POPULATIONS OF TOTAL VIABLE MICROORGANISMS & STREPTOCOCCI, & URINE CALCIUM LEVEL. AN INCREASE IN THE FRUCTOSYLTRANSFERASE ACTIVITY OF PLAQUE, IN POPULATIONS OF VEILLONELLA & STREPTOCOCCUS SANGUIS, & IN URINE PHOSPHORUS LEVELS ALSO OCCURRED.

EXPTL USE: SODIUM, CALCIUM, & MAGNESIUM TRIMETAPHOSPHATES WERE EQUALLY CAPABLE OF INHIBITING CARIOUS LESIONS IN RAT OCCLUSAL SULCI.

1

PPRTV Current

4

PPRTV Current

7.80e+04

1.20e+06

2.00e+04

1.5E+01(G)

1.00e+00

Volatile

2.30e+05

3.50e+06

6.00e+04

1.5E+01 (G)

1.00e+00

Volatile

Conditions of use: This substance is generally recognized as safe when used in accordance with good manufacturing practice.

Sodium metaphosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 454 kg. The toll free telephone number of the NRC is (800) 424-8802; In the Washington metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.6 (section IV. D.3.b).

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Condensed phosphates (CP) used as food additives depressed the growth of 7 strains of Streptococcus mutans (serotype a-g) as assessed by disk diffusion methods. Minimal inhibitory concn (MIC) of condensed phosphates on Streptococcus mutans appeared to be related to their chelating capacity. The antibacterial action of condensed phosphates seemed largely bacteriostatic. Condensed phosphates depressed lactate production from glucose and sucrose by the cells of strain Kl-R. Condensed phosphates depressed insoluble glucan production from sucrose by the cells of Kl-R. The inhibition of sugar metabolism may be due to the interference of sugar transport into Streptococcus mutans induced by the chelation effects of condensed phosphates. Hamsters were inoculated orally with strain Kl-R and reared on the high-sucrose diet No 2000 supplemented with 2% (wt/wt) condensed phosphates for 60 days. Dietary supplements of condensed phosphates were associated with reduced caries activity and plaque formation.

CIR ingredient: Sodium Trimetaphosphate

Used in toothpastes, synthetic dairy products, and detergents; [HSDB]

TOOTHPASTES CONTAINING 0.5-95% SILICON DIOXIDE XEROGEL & 0.5-6% SODIUM TRIMETAPHOSPHATE ARE EFFECTIVE TOOTH POLISHING AGENTS.

Sodium trimetaphosphate is used in synthetic dairy products (milk-based puddings) as a stabilizing agent.

In detergent processing.

Dental polishing agents, detergent builders, water softeners, sequestrants, emulsifiers, food additives, textile processing, laundering. /Sodium metaphosphate/

/Available from Monsanto Co as/ fine white powder, purified and technical grades ... purified grade meets FCC specifications on arsenic and heavy metals

TOOTHPASTES CONTAINING 0.5-95% SILICON DIOXIDE XEROGEL & 0.5-6% SODIUM TRIMETAPHOSPHATE ARE EFFECTIVE TOOTH POLISHING AGENTS.

Soap, Cleaning Compound, and Toilet Preparation Manufacturing

Metaphosphoric acid (H3P3O9), sodium salt (1:3): ACTIVE

Stabilizing salts ... phosphates are used in imitation dairy products for one of the following purposes to: alter buffering capacity of the system; improve stability of the protein to calcium ions; improve the heat stability of the protein; minimize the age gelation of ultra-high temperature (UHT) processed imitation products; serve as emulsifying salts in imitation cheese manufacture; and modify the water-binding capacity of proteins and improve solubility ... .