4-Phenylspiro[furan-2(3H),1'(3'H)-isobenzofuran]-3,3'-dion
Fluorescamine
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Grundinformationen
- CAS
38183-12-9- Standard-SMILES
O=C1OC2(OC=C(c3ccccc3)C2=O)c2ccccc21- InChIKey
ZFKJVJIDPQDDFY-UHFFFAOYSA-N- Summenformel
- C17H10O4
- Durchschnittliche Molmasse
- 278,26 g/mol
- Monoisotopische Masse
- 278,0579088
Überblick
A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent.
Namen und Bezeichner
- Bevorzugter Name
- Fluorescamine
- IUPAC
- 4'-phenylspiro[2-benzofuran-3,2'-furan]-1,3'-dione
- Lokaler Name
- 4-Phenylspiro[furan-2(3H),1'(3'H)-isobenzofuran]-3,3'-dion
- Englischer Name
- Fluorescamine
- Summenformel
- C17H10O4
- Molmasse
- 278.26
Namen und Synonyme
Fluorescamine38183-12-9FluramSpiro[furan-2(3H),1'(3'H)-isobenzofuran]-3,3'-dione, 4-phenyl-Y6859V58YWDTXSID50872017Spiro(furan-2(3H),1'(3'H)-isobenzofuran)-3,3'-dione, 4-phenyl-RO-20-7234RefChem:388984DTXCID30819622253-814-54'-phenylspiro[2-benzofuran-3,2'-furan]-1,3'-dione
Weitere Namen anzeigen
FluaramFLURAM(R)FluorescaminFluorescamineA.R.Fluorescamine, pureFLURAMANALYTICAL GRADEFluorescamine Labeling
4-Phenylspiro[furan-2(3H),1-phthalan]-3,3'-dioneMFCD00005928EINECS 253-814-5FLUORESCAMINE [MI]4-phenyl-3H,3'H-spiro[furan-2,1'-isobenzofuran]-3,3'-dioneRo 20-7234CS-3522AS-14756
Datenbank-Bezeichner
- CAS
38183-12-9
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,9
- Polarare Oberfläche (TPSA)
- 52,6 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 503
Experimentelle und physikochemische Eigenschaften
Chemical ClassesDyes -> Indicator Dyes
Physical DescriptionOff-white odorless powder; [Alfa Aesar MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 153 · 153-157 °C (lit.)
- Siedepunkt
- 381.08 °C · 381.08°C (rough estimate)
- Dichte
- 1.2661 · 1.2661 (rough estimate)
- Brechungsindex
- 1.5447 · 1.5447 (estimate)
- Flammpunkt
- -17 °C · -17 °C
- storage temp.
- room temp
- Löslichkeit
- acetonitrile: soluble
- Aggregatzustand
- powder
- Farbe
- off-white to yellow
- Wasserlöslichkeit
- Soluble in acetone, ethanol, chloroform, dimethylsulfoxide and acetonitrile. Slightly soluble in water.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationSpiro[furan-2(3H),1'(3'H)-isobenzofuran]-3,3'-dione, 4-phenyl-: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; [Alfa Aesar MSDS]
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- ridadr
- UN 1090 3/PG 2
- hs_code
- 29322090
- risk_code
- 11-36/38-66-67-36-36/37/38
- hazard_code
- F,Xi
- safety_code
- 22-24/25-36/37-33-29-26-16-9-37/39
- Speicherklasse
- 13 - Non Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Verwendung und Herstellung
UsesUsed as an analytical reagent; [Merck Index]
Anwendungen
VerwendenFluorescamine is a non-fluorescent reagent that reacts readily under mild conditions with primary amines in amino acids and peptides to form stable, highly fluorescent compounds. Reaction takes place under mild conditions. Low background due to hydrolysis.
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