sb 225002
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Grundinformationen
- CAS
182498-32-4- Standard-SMILES
O=C(Nc1ccc([N+](=O)[O-])cc1O)Nc1ccccc1Br- InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N- Summenformel
- C13H10BrN3O4
- Durchschnittliche Molmasse
- 352,144 g/mol
- Monoisotopische Masse
- 350,9854679
Namen und Bezeichner
- Bevorzugter Name
- sb 225002
- IUPAC
- N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
- Englischer Name
- SB 225002
- Summenformel
- C13H10BrN3O4
- Molmasse
- 352.14
Namen und Synonyme
SB 225002SB225002 ，S7651CAS:182498-32-4SB-225002SB 225002SB 225002 USP/EP/BPSB225002 182498-32-4SB225002, 10 mM in DMSOSB 225002, non-peptide CXCR2 antagonistSB 225002 - CAS 182498-32-4 - Calbiochem1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Datenbank-Bezeichner
- CAS
182498-32-4- PubChem CID
- 3854666
- DTXSID
DTXSID20397383- ChEMBL
CHEMBL239767- ChEBI
CHEBI:93074- UNII
- SSX8FD4H24
- EC Number
- 803-197-9
- Nikkaji
- J951.652B
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 401.6 · 401.6±45.0 °C(Predicted)
- Dichte
- 1.793 · 1.793±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- 100 mM · Soluble to 100mM in DMSO and to 50mM in ethanol
- Aggregatzustand
- Yellow solid
- pka
- 5.29 · 5.29±0.10(Predicted)
- Farbe
- white to beige
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChI
- 1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
- InChIKey
- MQBZVUNNWUIPMK-UHFFFAOYSA-N
- SMILES
- Brc1c(cccc1)NC(=O)Nc2c(cc(cc2)[N+](=O)[O-])O
- CAS Datenbank
- 182498 · 182498-32-4
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2921490090
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungCXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.
VerwendenSB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.
Anbieter100 Anbieter
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
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