Mupirocin Calcium
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Grundinformationen
- CAS
115074-43-6- Standard-SMILES
C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.O.O.[Ca+2]- InChIKey
DDHVILIIHBIMQU-YJGQQKNPSA-L- Summenformel
- C52H90CaO20
- Durchschnittliche Molmasse
- 1.075,3 g/mol
Überblick
Mupirocin calcium hydrate is a hydrate that is the dihydrate form of mupirocin calcium. It is an antibacterial drug used for the treatment of skin infections such as impetigo caused by Staphylococcus aureus and meticillin-resistant Staphylococcus aureus (MRSA). It has a role as an antiinfective agent, an antibacterial drug and a protein synthesis inhibitor. It contains a mupirocin calcium (anhydrous).
Namen und Bezeichner
- Bevorzugter Name
- Mupirocin Calcium
- IUPAC
- calcium;bis(9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate);dihydrate
- Englischer Name
- MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
- Summenformel
- C52H86CaO18.2H2O
- Molmasse
- 1075.34
Namen und Synonyme
Mupirocin calciumMupirocin calcium dihydratemupirocin calcium hydrateBRL 4910FBRL-4910FRG38I2P540CHEBI:34858DTXSID90883142PirnuoRefChem:55673DTXCID301510752Monocalcium bis(9-((2E)-4-((2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoate) dihydrate
Weitere Namen anzeigen
Mupirocin CaL-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, calcium salt (2:1), dihydrate, [2E,8[2S,3S(1S,2S)]]- (9CI)Unii-rg38I2p540Mopirocin calciumMUPIROCIN CALCIUM USPMupirocin Calcium (200 mg)Mupirocin Calcium (1448912)
115074-43-6BactrobanCalcium mupirocin dihydratemupirocin calcium saltBactroban (TN)Calcium pseudomonateCalcium 9-(((E)-4-((2S,3R,4R,5S)-3,4-dihydroxy-5-(((2S,3S)-3-((2S,3S)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoate dihydratecalcium;9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate;dihydrate
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 300 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 20
- Frei drehbare Bindungen
- 32
- Schwere Atome
- 73
- Formalladung
- 0
- Komplexität
- 689
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 132 · 132-139 °C
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 6 mg/mL · Water: 6 mg/mL (5.58 mM)
- InChIKey
- DDHVILIIHBIMQU-UGPPHRKUNA-L
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2941906000
- Toxizität
- mouse,LD50,intravenous,1638mg/kg (1638mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
MUPIROCIN CALCIUM
RNA Synthetase Inhibitors [MoA]; RNA Synthetase Inhibitor Antibacterial [EPC]
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
Anwendungen
VerwendenAntibacterial (topical).
Zugehörige Reaktionen
11
Notizen zur Verbindung
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