Mupirocin Calcium

HCID 5282317CAS 115074-43-6

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Grundinformationen

Standard-SMILES: C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.O.O.[Ca+2]
InChIKey: DDHVILIIHBIMQU-YJGQQKNPSA-L
Summenformel: C52H90CaO20
Durchschnittliche Molmasse: 1.075,3 g/mol

Überblick

Mupirocin calcium hydrate is a hydrate that is the dihydrate form of mupirocin calcium. It is an antibacterial drug used for the treatment of skin infections such as impetigo caused by Staphylococcus aureus and meticillin-resistant Staphylococcus aureus (MRSA). It has a role as an antiinfective agent, an antibacterial drug and a protein synthesis inhibitor. It contains a mupirocin calcium (anhydrous).

Namen und Bezeichner

Bevorzugter Name: Mupirocin Calcium
IUPAC: calcium;bis(9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate);dihydrate

Namen und Synonyme

Mupirocin calciumMupirocin calcium dihydratemupirocin calcium hydrateBRL 4910FBRL-4910FRG38I2P540CHEBI:34858DTXSID90883142PirnuoRefChem:55673DTXCID301510752Monocalcium bis(9-((2E)-4-((2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoate) dihydrate

Weitere Namen anzeigen

115074-43-6BactrobanCalcium mupirocin dihydratemupirocin calcium saltBactroban (TN)Calcium pseudomonateCalcium 9-(((E)-4-((2S,3R,4R,5S)-3,4-dihydroxy-5-(((2S,3S)-3-((2S,3S)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoate dihydratecalcium;9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate;dihydrate

Datenbank-Bezeichner

CAS: 115074-43-6
PubChem CID: 5282317
ChEMBL: CHEMBL3989715
ChEBI: CHEBI:34858
UNII: RG38I2P540
EC Number: 658-053-6

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 300 Å²
H-Brücken-Donoren: 8
H-Brücken-Akzeptoren: 20
Frei drehbare Bindungen: 32
Schwere Atome: 73
Formalladung: 0
Komplexität: 689

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

MUPIROCIN CALCIUM

RNA Synthetase Inhibitors [MoA]; RNA Synthetase Inhibitor Antibacterial [EPC]

MeSH Pharmacological Classification · 2 Einträge

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Substances that inhibit the growth or reproduction of BACTERIA.