Bactroban → Mupirocin Calcium

HRID 16667

Reaktionsgleichung

Reaktionsgleichung von HRID 16667
[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[Ca+2:71]>O>[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[OH2:4].[OH2:4].[Ca+2:71]

Komponenten

3

Edukt 1

HCID 6435927Bactroban

Produkt 1

HCID 5282317Mupirocin CalciumAusbeute 258,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Amorphous mupirocin calcium (14 g) was dissolved in water (35 ml) and stirred for one hour. The mixture was cooled to 5° C. and kept at this temperature for 15 hours. Then mixture was then stirred at 5° C. for 3 hours. The crystalline product was filtered and dried in an air circulated oven at room temperature. Mupirocin calcium dihydrate (12.5 g, 83%) was obtained.

Aufarbeitung

  1. waitkept at this temperature for 15 hours
  2. stirringThen mixture was then stirred at 5° C. for 3 hours
  3. filtrationThe crystalline product was filtered
  4. customdried in an air
  5. customat room temperature

Quellen und Nachweise

ORD-Eintrag
ord-8008fe19544b41a79c4b95d0460d93c7
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737177B2

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