Bactroban → Mupirocin Calcium

HRID 16668

Reaktionsgleichung

Reaktionsgleichung von HRID 16668
[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[Ca+2:71]>O>[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[OH2:4].[OH2:4].[Ca+2:71]

Komponenten

3

Edukt 1

HCID 6435927Bactroban2×

Produkt 1

HCID 5282317Mupirocin Calcium

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Amorphous mupirocin calcium (20.00 g, 19.20 mmole) was added into water (20 ml) under stirring. The slurry was stirred for 0.5 hour, and then it was cooled to 5° C. The mupirocin calcium solution was allowed to crystallize for 16 h. The crystal slurry was diluted with 15 ml water, and the crystals were filtered and washed with water (5 ml). The product (17.1 g) was dried at 35° C. for 12 h.

Aufarbeitung

  1. stirringThe slurry was stirred for 0.5 hour
  2. customto crystallize for 16 h
  3. additionThe crystal slurry was diluted with 15 ml water
  4. filtrationthe crystals were filtered
  5. washwashed with water (5 ml)
  6. dry with materialThe product (17.1 g) was dried at 35° C. for 12 h.

Quellen und Nachweise

ORD-Eintrag
ord-c603df2915db4aa49e683e2e9f3cc60b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737177B2

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