Eprosartan Mesylate

HCID 5282474CAS 144143-96-4

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Grundinformationen

Standard-SMILES: CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1.CS(=O)(=O)O
InChIKey: DJSLTDBPKHORNY-XMMWENQYSA-N
Summenformel: C24H28N2O7S2
Durchschnittliche Molmasse: 520,6 g/mol
Monoisotopische Masse: 520,13379358

Namen und Bezeichner

Bevorzugter Name: Eprosartan Mesylate
IUPAC: 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid;methanesulfonic acid
Englischer Name: Eprosartan mesylate
Summenformel: C24H28N2O7S2
Molmasse: 520.62

Namen und Synonyme

EPROSARTAN MESYLATETevetenEprosartan mesilateeprosartan methanesulfonateEprosartan MonomethanesulfonateSK&F 108566-JDTXSID7044217UNII-8N2L1NX8S3SK&F-108566-J8N2L1NX8S3DTXCID5024217CHEBI:48409

Weitere Namen anzeigen

Eprosartan MyslateEposartan mesylateMonomethanesulfonateEprosartanMesylate>Eprosartan mesylate, >=99%Eprosartan mesylate USP/EP/BPSunitinib and its interMediate

(E)-2-Butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic acid, monomethanesulfonateTEVETEN HCT COMPONENT EPROSARTAN MESYLATE2-Thiophenepropanoic acid, alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1H-imidazol-5-yl)methylene)-, (E)-, monomethanesulfonateEPROSARTAN MESILATE (MART.)EPROSARTAN MESILATE [MART.]EPROSARTAN MESYLATE (USP-RS)EPROSARTAN MESYLATE [USP-RS](E)-alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1H-imidazol-5-yl)methylene)-2-thiophenepropanoic acid monomethanesulfonate

Datenbank-Bezeichner

CAS: 144143-96-4
PubChem CID: 5282474
DTXSID: DTXSID7044217
ChEMBL: CHEMBL1200987
ChEBI: CHEBI:48409
UNII: 8N2L1NX8S3

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 183 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 9
Frei drehbare Bindungen: 10
Schwere Atome: 35
Formalladung: 0
Komplexität: 711

Physikochemische Eigenschaften

Schmelzpunkt: 248 · 248-250°
storage temp.: Sealed in dry,Room Temperature
Löslichkeit: 10 mg/mL · DMSO: >10mg/mL
Aggregatzustand: powder
Farbe: white to off-white
Merck: 14 · 14,3635
Major Application: pharmaceutical (small molecule)
InChIKey: DJSLTDBPKHORNY-XMMWENQYSA-N
SMILES: S(O)(=O)(=O)C.C(C1C=CC(C(=O)O)=CC=1)N1C(=NC=C1/C=C(/C(=O)O)\CC1SC=CC=1)CCCC
CAS Datenbank: 144143 · 144143-96-4(CAS DataBase Reference)

Sicherheit und Regulatorisches

Toxikologische Informationen

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Eprosartan mesylate

Ambiguous-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation · 1 Eintrag

◉ Summary of Use during Lactation；Eprosartan is no longer marketed in the US. Because no information is available on the use of eprosartan during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.；◉ Effects in Breastfed Infants；Relevant published information was not found as of the revision date.；◉ Effects on Lactation and Breastmilk；Relevant published information was not found as of the revision date.