Methanesulfonic Acid → Eprosartan Mesylate

HRID 1037677

Reaktionsgleichung

Reaktionsgleichung von HRID 1037677
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=2)[C:8](/[CH:20]=[C:21](/[C:28]([OH:30])=[O:29])\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)=[CH:7][N:6]=1.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]>C(O)(=O)C>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=2)[C:8](/[CH:20]=[C:21](/[C:28]([OH:30])=[O:29])\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)=[CH:7][N:6]=1.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 5281037Eprosartan

Produkt 1

HCID 5282474Eprosartan Mesylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

An embodiment of the present invention is as follows: eprosartan is dissolved or suspended in glacial acetic acid, then methanesulfonic acid is added and stirred to obtain a solution of eprosartan mesylate in glacial acetic acid, the precipitated solid is stirred and filtered to obtain a solid of eprosartan mesylate, or glaicial acetic acid is concentrated to dry to obtain a solid of eprosartan mesylate, or an organic ester solvent is added dropwise to the glacial acetic acid under stirring to precipitate crystal and separate to obtain a solid of eprosartan mesylate, wherein the ratio of eprosartan (mass, g): methanesulfonic acid (mass, g): glacial acetic acid (volume, ml) is 1:0.1-5.0:1-15, and the temperature of reaction is 10° C.-110° C.

Quellen und Nachweise

ORD-Eintrag
ord-92fcf26e3c7047f6bae52ea452360d6e
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546585B2

Verknüpfte Notizen

Wird geladen…