Undecylenic Acid
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Grundinformationen
- CAS
112-38-9- Standard-SMILES
C=CCCCCCCCCC(=O)O- InChIKey
FRPZMMHWLSIFAZ-UHFFFAOYSA-N- Summenformel
- C11H20O2
- Durchschnittliche Molmasse
- 184,27 g/mol
- Monoisotopische Masse
- 184,14632988
Überblick
10-undecenoic acid is an undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems. It has a role as a plant metabolite and an antifungal drug. It is a conjugate acid of a 10-undecenoate.
Namen und Bezeichner
- Bevorzugter Name
- Undecylenic Acid
- IUPAC
- undec-10-enoic acid
- Englischer Name
- Undecenoic acid
- Summenformel
- C11H20O2
- Molmasse
- 184.28
Namen und Synonyme
undecylenic acid10-UNDECENOIC ACIDUndec-10-enoic acid112-38-910-Hendecenoic acidRenselinSevinonDeclid10-Undecylenic acidundecylenateKyselina undecylenovaFEMA No. 3247
Weitere Namen anzeigen
FEMA 3247undecylenic9-Undecenoic acidundecyl-10-enicacidUndecenoic
UNDECEN-10-ACID-1omega-undecenoic acidomega-hendecenoic acidDTXSID8035001NSC-2013K3D86KJ24NCHEBI:35045NSC2013
Datenbank-Bezeichner
- CAS
112-38-9、1333-28-4、96451-28-4- PubChem CID
- 5634
- DTXSID
DTXSID8035001- ChEMBL
CHEMBL1276010- ChEBI
CHEBI:35045- UNII
- K3D86KJ24N
- EC Number
- 203-965-8、215-583-9、619-214-6
- Nikkaji
- J5.125J
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 3,9
- Polarare Oberfläche (TPSA)
- 37,3 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 141
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Classes -> Organic Acids
LipidsFatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Unsaturated fatty acids [FA0103]
Cosmetics
Cosmetic ingredients (Undecylenic Acid) -> CIR (Cosmetic Ingredient Review)
Preservative; Cleansing
SpringerMaterials PropertiesBoiling point
FragrancesFragrance Ingredient (10-Undecenoic acid) -> IFRA transparency List
LogP
3.86
3.86
Food AdditivesFLAVORING AGENT OR ADJUVANT -> FDA Substance added to food
Density0.910 - 0.917
Flavoring AgentsEU Flavoring substances
Solubility
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 1915 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: 10-Undecenoic acid
Chemical: Undecenoic acid
10-Undecenoic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 10-Undecenoic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Undec-10-enoic acid (EC: 203-965-8)
Undecylenic acid: HSNO Approval: HSR003810 Approved with controls
Other Safety Information
IMAP assessments - 10-Undecenoic acid: Human health tier I assessment
Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards Summary
Safe when used as a flavoring agent in food; [JECFA] A severe skin irritant; Causes somnolence, excitement, and muscle contraction or spasticity in oral lethal-dose studies of mice; Causes other changes in blood in 3-day intermittent dermal study of mice (15,000 mg/kg); [RTECS] A skin and strong eye irritant; [Alfa Aesar MSDS]
EPA Safer ChemicalChemical: Undecylenic acid
Chemie und Industrie
Pharmakologische Informationen
ATC Code
D - Dermatologicals
QD - Dermatologicals
Protein BindingNo information regarding protein binding.
Pharmacodynamics
Zinc undecylendate acts as a fungistatic agent but fungicidal activity may be observed with chronic exposure in high concentrations. It is effective against _Candida albicans_. It is proposed that undecylenic acid exerts antimicrobial actions via interacting with nonspecific components in the cell membrane.
Mechanism of Action
Undecylenic acid demonstrated effectiveness against _Candida albicans_, which is an opportunistic pathogenic yeast with two cellular morphologies: the round yeast form and the filamentous form with elongated hyphae. Hyphae formation is associated with active infections and virulence. A study proposed that undecylenic acid inhibits biofilm formation of _Candida albicans_ with optimal concentration above 3 mM and disrupts hyphal growth, which is the morphological transition from yeast to filamentous phase, at concentration above 4 mM. Under the drug treatment, hyphal formation related genes, like HWP1, were significantly reduced in transcriptional level leading to poor biofilm formation. Both biofilm and hyphae formation are critical virulence factors for the initiation of skin infection and late development of disseminated infection. Undecylenic acid may also inhibit enzyme involved in lipid metabolism and abolish germ tube formation by carrying protons across the plasma membrane, thus altering cytoplasmic pH.
Biological Half-LifeNo information regarding half-life.
Metabolism/MetabolitesNo information regarding metabolism.
Absorption, Distribution and Excretion
Undecylenic acid may be absorbed through the skin [MSDS].
No information regarding route of elimination.
No information regarding volume of distribution.
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