N-(Tri(hydroxymethyl)methyl)glycin
Tricine
Grundinformationen
- CAS
5704-04-1- Standard-SMILES
O=C(O)CNC(CO)(CO)CO- InChIKey
SEQKRHFRPICQDD-UHFFFAOYSA-N- Summenformel
- C6H13NO5
- Durchschnittliche Molmasse
- 179,17 g/mol
- Monoisotopische Masse
- 179,07937252
Überblick
N-tris(hydroxymethyl)methylglycine is a Good's buffer substance, pKa = 8.15 at 20 C. It is functionally related to a glycine and a member of tris. It is a tautomer of a N-tris(hydroxymethyl)methylammonioacetate.
Namen und Bezeichner
- Bevorzugter Name
- Tricine
- IUPAC
- 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
- Lokaler Name
- N-(Tri(hydroxymethyl)methyl)glycin
- Englischer Name
- Tricine
- Summenformel
- C6H13NO5
- Molmasse
- 179.17
Namen und Synonyme
Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidW12LH4V8V3NSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine
Weitere Namen anzeigen
TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8
2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -5,1
- Polarare Oberfläche (TPSA)
- 110 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 137
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Uses -> Biological Buffers
Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 186 · 186-188 °C (dec.)
- Siedepunkt
- 311.69 °C · 311.69°C (rough estimate)
- Dichte
- 1.05 g/mL · 1.05 g/mL at 20 °C
- Dampfdruck
- 0.002 · 0.002-0.004Pa at 20-25℃
- Brechungsindex
- 1.424 · 1.4240 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- 2 O: · H2O: 4 M at 20 °C, clear, colorless
- Aggregatzustand
- crystalline
- Farbe
- clear colorless (40 % (w/w) in H2O) solution
- Geruch (Odor)
- Odorless
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.
Not Classified
Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
REACH registered substance: N-(tri(hydroxymethyl)methyl)glycine (EC: 227-193-6)
Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- F
- 3
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29052900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36-36/37/39
- Speicherklasse
- 13 - Non Combustible Solids
Chemie und Industrie
Verwendung und Herstellung
UsesUsed as a biological buffer; [Merck Index]
General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE
Anwendungen
VerwendenGood's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).
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