Tricine (HCID 79784)

Namen und Bezeichner

Bevorzugter Name: Tricine
IUPAC: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
Lokaler Name: N-(Tri(hydroxymethyl)methyl)glycin
Englischer Name: Tricine
Summenformel: C6H13NO5
Molmasse: 179.17

Namen und Synonyme

Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-W12LH4V8V32-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidNSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine

Weitere Namen anzeigen

TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8

2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine

Datenbank-Bezeichner

CAS: 5704-04-1
PubChem CID: 79784
DTXSID: DTXSID1063982
ChEBI: CHEBI:39063
UNII: W12LH4V8V3
EC Number: 227-193-6
Nikkaji: J135.902I

Eigenschaften

Berechnete Struktureigenschaften

XLogP: -5,1
Polarare Oberfläche (TPSA): 110 Å²
H-Brücken-Donoren: 5
H-Brücken-Akzeptoren: 6
Frei drehbare Bindungen: 6
Schwere Atome: 12
Formalladung: 0
Komplexität: 137

Experimentelle und physikochemische Eigenschaften

Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt: 186 · 186-188 °C (dec.)
Siedepunkt: 311.69 °C · 311.69°C (rough estimate)
Dichte: 1.05 g/mL · 1.05 g/mL at 20 °C
Dampfdruck: 0.002 · 0.002-0.004Pa at 20-25℃
Brechungsindex: 1.424 · 1.4240 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit: 2 O: · H2O: 4 M at 20 °C, clear, colorless
Aggregatzustand: crystalline
Farbe: clear colorless (40 % (w/w) in H2O) solution
Geruch (Odor): Odorless
PH: 4 · 4.0-6.0 (1M in H2O)
pka: 8.1 · 8.1(at 25℃)
Biologische Quelle: synthetic
Wasserlöslichkeit: soluble
Merck: 14 · 14,9651
BRN: 1937804 · 1937804
Stabilität: Stable.
InChI: 1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
InChIKey: SEQKRHFRPICQDD-UHFFFAOYSA-N
SMILES: OCC(CO)(CO)NCC(O)=O
LogP: -2.87 at · -2.87 at 25℃
CAS Datenbank: 5704 · 5704-04-1(CAS DataBase Reference)
EPA chemische Informationen: 2 · Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- (5704-04-1)
Absorption: 0.05 at · ≤0.05 at 280 in H2O at 1M≤0.1 at 260 in H2O at 1M

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 3 Einträge

This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 121 of 124 companies (only 2.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 121 of 124 reports by companies.；There are 3 notifications provided by 3 of 124 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesNot Classified

Regulatorische Informationen

Regulatory Information · 3 Einträge

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

F: 3
wgk: 3
tsca: TSCA listed
hs_code: 29052900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36-36/37/39
Speicherklasse: 13 - Non Combustible Solids

Chemie und Industrie

Verwendung und Herstellung

UsesUsed as a biological buffer; [Merck Index]

General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE

Anwendungen · 1 Eintrag

VerwendenGood's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).