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Manganese acetate tetrahydrate

HCID 93021
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Grundinformationen

CAS
6156-78-1
Standard-SMILES
CC(=O)[O-].CC(=O)[O-].O.O.O.O.[Mn+2]
InChIKey
CESXSDZNZGSWSP-UHFFFAOYSA-L
Summenformel
C4H6MnO4 . 4H2O
Durchschnittliche Molmasse
245,09 g/mol
Monoisotopische Masse
245,00691

Überblick

Manganese triacetate is a chemical compound of manganese. Manganese is a naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in its pure form, but is found in many types of rocks in combination with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay healthy, as manganese ions act as cofactors for a number of enzymes. (L228, L229)

Namen und Bezeichner

Bevorzugter Name
Manganese acetate tetrahydrate
IUPAC
manganese(2+);diacetate;tetrahydrate
Englischer Name
Manganese(II) acetate tetrahydrate
Summenformel
C4H14MnO8
Molmasse
245.09

Namen und Synonyme

6156-78-1Manganese acetate tetrahydrateManganese(II) acetate tetrahydrateManganous acetate tetrahydrateManganese diacetate, tetrahydratemanganese diacetate tetrahydrateMANGANUM ACETICUMUNII-9TO51D176NDTXSID002105669TO51D176NDTXCID30133057RefChem:59029
Weitere Namen anzeigen
MANGANESE ACETATEMANGANESE(II) ACETATECo-MnManganeseAcetateAracetate tetrahydrateManganese acetate, GR 99%+MANGANESE(II) ACETATE 4 H2OTetrahydrate of acetic acid
C4H14MnO8manganese (II) acetate tetrahydrate4-BENZOYLBENZENEBORONICACIDACETIC ACID, MANGANESE(2+) SALT, TETRAHYDRATEManganese(II); acetate tetrahydrateManganeseacetatetetrahydratemanganous;diacetate;tetrahydrateMANGANUM ACETICUM [HPUS]

Datenbank-Bezeichner

CAS

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
84,3 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
8
Frei drehbare Bindungen
0
Schwere Atome
13
Formalladung
0
Komplexität
25,5

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Organic Acids, Metal Salts
Density1.59 @ 20°C
Melting Point80 °C
Physical DescriptionLight red transparent solid; [Merck Index] Light pink hygroscopic crystals; [Acros Organics MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
300 °C · >300 °C(lit.)
Dichte
1.589 g/mL · 1.589 g/mL at 25 °C(lit.)
Dampfdruck
1 hPa · <1 hPa (25 °C)
storage temp.
30 °C · Store below +30°C.
Löslichkeit
233 g/l · 233g/l
Aggregatzustand
Crystals
Wichte
1.589 · 1.589
Farbe
Pink
PH
7 · 7.0 (50g/l, H2O, 20℃)
Wasserlöslichkeit

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 35.1% (26 of 74) of reports.

Warning

H315 (63.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 74 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Gefahrenhinweise

Regulatory Information · 2 Einträge

Chemical: Acetic acid, manganese(2+) salt, tetrahydrate

Acetic acid, manganese(2+) salt, tetrahydrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Soluble manganese compounds: Human health tier II assessment
Hazards SummaryAn irritant; Possible reproductive and fetal toxicant; [Acros Organics MSDS] See Manganese(II) acetate. See Manganese and linked occupational diseases.
Hazard Classes and Categories · 2 Einträge

Skin Irrit. 2 (63.5%)

Acute toxicity (ingestion) - category 4

Sicherheit und Schutzausrüstung

Exposure Control and Personal Protection0.2 [mg/m3], as Mn (inhalable fraction), 0.02 mg/m3, as Mn (respirable fraction)[German Research Foundation (DFG)]

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Manganese is absorbed mainly via ingestion, but can also be inhaled. It binds to alpha-2-macroglobulin, albumin, or transferrin in the plasma and is distributed to the brain and all other mammalian tissues, though it tends to accumulate more in the liver, pancreas, and kidney. Manganese is capable of existing in a number of oxidation states and is believed to undergo changes in oxidation state within the body. Manganese oxidation state can influence tissue toxicokinetic behavior, and possibly toxicity. Manganese is excreted primarily in the faeces. (L228)

FDA Pharmacological Classification · 4 Einträge

MANGANESE ACETATE TETRAHYDRATE

Magnetic Resonance Contrast Activity [MoA]; Paramagnetic Contrast Agent [EPC]

MANGANUM ACETICUM

Osmotic Laxative [EPC]; Magnesium Ion Exchange Activity [MoA]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Increased Large Intestinal Motility [PE]; Calculi Dissolution Agent [EPC]; Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]

Verwendung und Herstellung

Uses · 2 Einträge

Used as a mordant in dyeing, to make a brown pigment, and as a drying agent for paints and varnishes; [Merck Index]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Anwendungen

VerwendenManganese(II) acetate tetrahydrate may be used in the sol gel synthesis of doped TiO2 containing different amounts of Mn2+.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

ManganEssigsure

Zugehörige Reaktionen

46
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Weitere Aktionen
Neue NotizNeue ReaktionAnfrage stellen
6156-78-1
PubChem CID
93021
DTXSID
DTXSID00210566
UNII
9TO51D176N
EC Number
612-176-1、927-058-8
Soluble in water, methanol, ethanol, and acetic acid.
Merck
14 · 14,5724
BRN
3730728 · 3730728
InChI
1S/2C2H4O2.Mn.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2
InChIKey
SLMRUTJYVMZEPJ-UHFFFAOYSA-M
SMILES
[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(=O)O[Mn]OC(C)=O
CAS Datenbank
6156 · 6156-78-1(CAS DataBase Reference)
Minimum Risk LevelChronic Inhalation: 0.0003 mg/m3 (L134)
Threshold Limit Values (TLV)0.02 [mg/m3], as Mn (respirable fraction), 0.1 mg/m3, as Mn (inhalable fraction)
Protective Action Criteria (PAC) · 3 Einträge

13 [mg/m3]

22 [mg/m3]

740 [mg/m3]

Toxikologische Informationen

Health Effects · 1 Eintrag

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Adverse EffectsNeurotoxin - Parkinsonism
Exposure RoutesOral (L228) ; inhalation (L228)
Toxicity Summary · 1 Eintrag

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228)

Signs and Symptoms · 1 Eintrag

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Sicherheitsdaten

wgk
2
tsca
Yes
hs_code
29152990
RTECS-Nr.
AI5775000
risk_code
36/37/38
Toxizität
LD50 orally in Rabbit: 3730 mg/kg
hazard_code
Xi
safety_code
26-36
Speicherklasse
11 - Combustible Solids
Hazard Classifications
Aquatic Chronic 3STOT RE 2 Inhalation
Mangandi(acetat)

Nachgelagerte Produkte

IsophthalsureKetorolacBleidi(acetat)