4-(3-Chloropropyl)morpholine
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Grundinformationen
- CAS
7357-67-7- Standard-SMILES
ClCCCN1CCOCC1- InChIKey
PIAZYBLGBSMNLX-UHFFFAOYSA-N- Summenformel
- C7H14ClNO
- Durchschnittliche Molmasse
- 163,64 g/mol
- Monoisotopische Masse
- 163,07639175
Namen und Bezeichner
- Bevorzugter Name
- 4-(3-Chloropropyl)morpholine
- IUPAC
- 4-(3-chloropropyl)morpholine
- Englischer Name
- 4-(3-Chloropropyl)morpholine
- Summenformel
- C7H14ClNO
- Molmasse
- 163.65
Namen und Synonyme
4-(3-Chloropropyl)morpholineN-(3-Chloropropyl)morpholineMorpholine, 4-(3-chloropropyl)-82BVM8E6TNNSC 38889NSC-38889DTXSID70223769RefChem:97141DTXCID50146260461-510-0691-245-87357-67-7
Weitere Namen anzeigen
Gefitinib iMpurity A4-(3-ChLNSC 28831)-morphoLN-(3-Chloropropyl)MIFLAB-BB F2108-0002Gefitinib IMpurity VIGefitinib Impurity 81
1-Chloro-3-morpholinopropane3-Morpholinopropyl chlorideMFCD000397144-(3-Chloro-propyl)-morpholinechloropropylmorpholine4-(3-chloropropyl)-morpholineUNII-82BVM8E6TN4-(3-chloropropyl) morpholine
Datenbank-Bezeichner
- CAS
7357-67-7- PubChem CID
- 95834
- DTXSID
DTXSID70223769- UNII
- 82BVM8E6TN
- EC Number
- 461-510-0、691-245-8、943-703-6
- Nikkaji
- J46.692A
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 0,8
- Polarare Oberfläche (TPSA)
- 12,5 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 10
- Formalladung
- 0
- Komplexität
- 83,7
Physikochemische Eigenschaften
- Schmelzpunkt
- NA
- Siedepunkt
- 115 °C/25mmHg · 115°C/25mmHg(lit.)
- Dichte
- 1.0409 g/cm3 · 1.0409 g/cm3
- Brechungsindex
- 1.472 · 1.4720-1.4760
- Flammpunkt
- 91 °C · 91 °C
- storage temp.
- -20 °C · Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Oil
- pka
- 7.03 · 7.03±0.10(Predicted)
- Wichte
- 1.08 · 1.08
- Farbe
- Colourless to Yellow
- InChI
- InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
- InChIKey
- PQECODMSWJOUAT-UHFFFAOYSA-N
- SMILES
- N1(CCCCl)CCOCC1
- CAS Datenbank
- 7357 · 7357-67-7(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302+H312+H332 (12.5%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 8 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
Gefahrenhinweise
Regulatory InformationStatus: Active Update: 05-06-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/28401
Hazard Classes and Categories
Acute Tox. 4 (50%)
Acute Tox. 4 (62.5%)
Acute Tox. 4 (100%)
Sicherheitsdaten
- hs_code
- 2934999090
- risk_code
- 36/37/38
- safety_code
- 26-36/37/39
- hazard_class
- IRRITANT
Chemie und Industrie
Anwendungen
Beschreibung4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.
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