1-Bromo-3-chloropropane → 4-(3-Chloropropyl)morpholine

HRID 22775

Reaktionsgleichung

Reaktionsgleichung von HRID 22775
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][Cl:11]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][CH2:9][CH2:10][Cl:11])[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 80061-Bromo-3-chloropropaneHCID 8083Morpholine

Produkt 1

HCID 958344-(3-Chloropropyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of morpholine (52.2 ml), 1-bromo-3-chloropropane (30 ml) and toluene (180 ml) was heated to 70° C. for 3 hours. The solid was removed by filtration and the filtrate was evaporated under vacuum. The resultant oil was decanted from the additional solid which was deposited and the oil was purified by vacuum distillation to yield 3-morpholinopropyl chloride (37.91 g); NMR Spectrum: (DMSOd6) 1.85 (m, 2H), 2.3 (t, 4H), 2.38 (t, 2H), 3.53 (t, 4H), 3.65 (t, 2H).

Aufarbeitung

  1. customThe solid was removed by filtration
  2. customthe filtrate was evaporated under vacuum
  3. customThe resultant oil was decanted from the additional solid which
  4. distillationthe oil was purified by vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-a049d93aa79344ffb2fda0463cf54c65
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849625B2

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