N-(4-Chloro-2-nitrophenyl)benzenesulfonamide → 2-Phenylsulfonylamino-5-chloroaniline

HRID 1006535

Reaktionsgleichung

[C:1]1([S:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[N+:18]([O-])=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)(=O)C.C(OCC)(=O)C>[C:1]1([S:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[NH2:18])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

Reaktionsbedingungen

Temperatur: 120 °C

Versuchsvorschrift

To a solution of 2-phenylsulfonylamino-5-chloro-1-nitrobenzene (172 mg; prepared in Reference Example 11.) in acetic acid (4 ml), reduced iron powder (154 mg) was added at room temperature under an atmosphere of argon. The suspension was stirred for 2 hours at 120° C. The reaction suspension was diluted with ethyl acetate and filtered. The filtrate was concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (AcOEt-hexane) to give the title compound (92 mg) having the following physical data.

Aufarbeitung

filtrationfiltered
concentrationThe filtrate was concentrated under the reduced pressure
customThe residue was purified on silica gel column chromatography (AcOEt-hexane)

Quellen und Nachweise

ORD-Eintrag: ord-1c1d627ad067465f96f9378ff0f0da55
Quelldatensatz: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06790866B2

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