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Methyl Ethyl Ketone → Ethyl 4-(2-Piperidinoethoxy)benzoate

HRID 1007854
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1007854
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Cl.Cl[CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C(=O)([O-])[O-].[K+].[K+].C(C(C)=O)C>O.C(OCC)(=O)C.C(#N)C.C(N(CC)CC)C>[N:17]1([CH2:16][CH2:15][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 6569Methyl Ethyl KetoneHCID 8434EthylparabenHCID 11430Potassium CarbonateHCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochloride3×

Produkt 1

HCID 9838504Ethyl 4-(2-Piperidinoethoxy)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962
Water
Lösungsmittel
HCID 86586431Ethyl acetate acetonitrile triethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of ethyl 4-hydroxybenzoate (8.31 g), 1-(2-chloroethyl)piperidine monohydrochloride (10.13 g), potassium carbonate (16.59 g), and methyl ethyl ketone (60 mL) was heated to 80° C. After one hour, the mixture was cooled to about 55° C. and treated with additional 1-(2-chloroethyl)piperidine mono-hydrochloride (0.92 g). The resulting mixture was heated to 80° C. The reaction was monitored by thin layer chromatography (TLC), using silica-gel plates and ethyl acetate/acetonitrile/triethylamine (10:6:1, v/v). Additional portions of 1-(2-chloroethyl)piperidine hydrochloride are added until the starting 4-hydroxybenzoate ester is consumed. Upon complete reaction, the reaction mixture was treated with water (60 mL) and allowed to cool to room temperature. The aqueous layer was discarded and the organic layer concentrated in vacuo at 40° C. and 40 mm Hg. The resulting oil was used in the next step without further purification.

Aufarbeitung

  1. temperaturethe mixture was cooled to about 55° C.
  2. temperatureThe resulting mixture was heated to 80° C
  3. customis consumed
  4. customUpon complete reaction
  5. temperatureto cool to room temperature
  6. concentrationthe organic layer concentrated in vacuo at 40° C.
  7. customThe resulting oil was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7e4de56e631f4ea0a2fe41983119dcf4
Quelldatensatz
uspto-grants-2004_09
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06797719B2

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