Water → 3,3-Dimethoxypropanoic acid lithium salt

HRID 10110

Reaktionsgleichung

Reaktionsgleichung von HRID 10110
C[O:2][C:3](=[O:10])[CH2:4][CH:5]([O:8][CH3:9])[O:6][CH3:7].O[Li:12].O.O>C1COCC1>[Li+:12].[CH3:7][O:6][CH:5]([O:8][CH3:9])[CH2:4][C:3]([O-:10])=[O:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 81924Methyl 3,3-dimethoxypropionateHCID 168937Lithium hydroxide, monohydrate

Produkt 1

HCID 876652803,3-Dimethoxypropanoic acid lithium saltAusbeute 98,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048–2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH.H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).

Aufarbeitung

  1. temperatureto reflux for 4 hours
  2. dry with materialazeotropically dried from THF (4 times)

Quellen und Nachweise

ORD-Eintrag
ord-1760007316da4df791d25f5e9c52543d
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091372B2

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