Lithium Hydroxide → 5-Methoxyquinoline-3-carboxylic acid

HRID 1011429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011429
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:13]=[N:14]2)C1C=CC=CC=1.[Li+].[OH-]>C1COCC1.O>[CH3:1][O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[CH:13]=[N:14]2

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 23159744HCID 23159744, Verbindung

Produkt 1

HCID 231597415-Methoxyquinoline-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of ethyl 5-methoxyquinoline-3-carboxylate (2.31 g, 10 mmol) prepared in stage B of example 2 and LiOH (0.4 g, 20 mmol) in THF (20 mL) and water (0.5 mL) was refluxed for 2 hours. After cooling, the solvents were evaporated under vacuum. The solid residue was used in the next step without further purification.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe solvents were evaporated under vacuum
  3. customThe solid residue was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-28339260fa2744bba8e1de1f258a4b27
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977354B2

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