Reaktionsgleichung
[CH:1]1([CH:9]=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:11]1(=O)[CH2:18]CCCCC[CH2:12]1.[CH:20]1([CH:26]=O)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C([O:35][C:36](=[O:45])[C:37]1[CH:42]=[C:41]([NH2:43])[CH:40]=[CH:39][C:38]=1[CH3:44])C1C=CC=CC=1.C(OC(=O)C1C=CC=C([NH2:61])C=1)C1C=CC=CC=1.C[NH:64][CH2:65][C@@H:66]([C@H]([C@@H]([C@@H](CO)O)O)O)[OH:67].O.[O:77]1[CH2:82][CH2:81]OCC1>O>[C:20]12([O:67][CH2:66][C:65]3[NH:64][C:9]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]4)=[N:61][C:81]=3[C:82]([NH:43][C:41]3[CH:40]=[CH:39][C:38]([CH3:44])=[C:37]([CH:42]=3)[C:36]([OH:35])=[O:45])=[O:77])[CH2:21][CH:22]3[CH2:23][CH:24]([CH2:18][CH:11]([CH2:12]3)[CH2:26]1)[CH2:25]2Komponenten
Edukt 7
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The title compound was prepared according to the procedure of Example 216, with the modification that cyclooctanecarboxaldehyde (prepared from cyclooctanone according to the procedure given in Example 205, steps a and b) was used in step d instead of cyclohexanecarboxaldehyde and 5-amino-2-methyl-benzoic acid benzyl ester replaced 3-amino-benzoic acid benzyl ester in step f. 1H NMR (300 MHz, d6-DMSO) 12.40 (1H, br s), 12.10 (1H, br s), 9.55 (1H, br s), 8.29 (1H, s), 7.78 (1H, d), 7.20 (1H, d), 4.78 (2H, s), 2.96 (1H, m), 2.45 (3H, s), 2.10-1.53 (29H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 61.55; H, 8.31; N, 7.60%; C38H58N4O9.1.5 H2O requires: C, 61.52; H, 8.28; N, 7.55%.
Quellen und Nachweise
- ORD-Eintrag
- ord-c4d0f9fb473d44218978e06e588bb61d
- Quelldatensatz
- uspto-grants-2002_11
- Patentnummer
- US06479531B1
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