Lithium Hydroxide → HCID 61728386, Verbindung

HRID 1020016Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020016
[CH3:1][N:2]([CH3:20])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[CH:12][C:11]([C:16]([O:18]C)=[O:17])=[CH:10]2)=[CH:5][CH:4]=1.[OH-].[Li+]>CO.O>[CH3:1][N:2]([CH3:20])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[CH:12][C:11]([C:16]([OH:18])=[O:17])=[CH:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 68154733HCID 68154733, Verbindung

Produkt 1

HCID 61728386HCID 61728386, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

After 357 mg (1.31 mmol) of methyl 1-(4-dimethylaminophenyl)-1,6-dihydro-6-oxo-3-pyridinecarboxylate was dissolved in 12 mL of methanol and 4 mL of water, 94 mg (3.93 mmol) of lithium hydroxide was added to the solution. Afterward, the resulting reaction solution was stirred at about 50° C. for about 5 hours. After termination of the reaction was determined by liquid chromatography, the solvent was removed in vacuo, and aqueous HCl was then added to the reaction solution to titrate until a neutral solution was obtained. The resulting solid compound was filtrated and used in Example 113-3 without an additional purification process.

Aufarbeitung

  1. customAfterward, the resulting reaction solution
  2. customthe solvent was removed in vacuo, and aqueous HCl
  3. additionwas then added to the reaction solution
  4. customwas obtained
  5. filtrationThe resulting solid compound was filtrated

Quellen und Nachweise

ORD-Eintrag
ord-76e9f618f7094176bbf5e6757e406dd0
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716309B2

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