Diisopropylcarbodiimide → N,N'-Bis(1-methylethyl)urea

HRID 1028859

Reaktionsgleichung

Reaktionsgleichung von HRID 1028859
Cl.C([O:4]C(=O)[C@H](CC1C=CC=CC=1)N)C.[CH:16]([N:19]=[C:20]=[N:21][CH:22]([CH3:24])[CH3:23])([CH3:18])[CH3:17].C(N(C(C)C)CC)(C)C>O>[CH:16]([NH:19][C:20](=[O:4])[NH:21][CH:22]([CH3:24])[CH3:23])([CH3:18])[CH3:17]

Komponenten

5

Edukt 3

HCID 12734DiisopropylcarbodiimideHCID 81531DiisopropylethylamineHCID 165085Ethyl L-phenylalaninate hydrochloride

Produkt 1

HCID 20084N,N'-Bis(1-methylethyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Then 11.5 g (50 mM) of Phenylalanine Ethyl Ester hydrochloride and 7.75 mL (45 mM) of diisopropylcarbodiimide were added. Then 8.6 mL (50 mM) of diisopropylethylamine was added via the dropping funnel for 10 min. The reaction mixture was kept for 20 hours at a room temperature, then 10 mL of H2O was added, a precipitate of diisopropylurea formed was filtered off, a resulted solution was analyzed by HPLC. According analysis, the reaction was completed at 50%.

Quellen und Nachweise

ORD-Eintrag
ord-f920496197c1476e8361f7ae5bb4c5a4
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735623B2

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