Formic Acid → 2-Methyl-4-nitrophenylformamide

HRID 1029860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1029860
[CH3:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH:12](O)=[O:13]>>[CH:12]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([N+:9]([O-:11])=[O:10])=[CH:8][C:2]=1[CH3:1])=[O:13]

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 74412-Methyl-4-nitroaniline

Produkt 1

HCID 35570182-Methyl-4-nitrophenylformamideAusbeute 95 %

Versuchsvorschrift

1000 g of formic acid were introduced into a flask fitted with a stirrer and a reflux condenser. 151 g (1 mol) of 2-methyl-4-nitroaniline were added, and the resultant mixture was slowly heated to the reflux point. After four hours, the reaction mixture was poured into 5 l of ice water. The resultant precipitate was filtered off with suction, washed with water until neutral and then dried at 60° C. under reduced pressure. Recrystallization of the resultant crude product from 2.5 l of methanol or ethanol gave 171 g of N-formyl-2-methyl-4-nitroaniline (yield: 95%) as yellow crystals, which melted at 162° C.

Aufarbeitung

  1. customfitted with a stirrer and a reflux condenser
  2. filtrationThe resultant precipitate was filtered off with suction
  3. washwashed with water until neutral and
  4. customthen dried at 60° C. under reduced pressure
  5. customRecrystallization of the resultant crude product from 2.5 l of methanol or ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f3a3f8e76b12467593eb727369d48180
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05103060

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