Ammonia → 3'-Amino-4'-methoxyacetanilide

HRID 1030863

Reaktionsgleichung

Reaktionsgleichung von HRID 1030863
[N+:1]([C:4]1[CH:9]=[C:8]([NH:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:6][C:5]=1[O:14][CH3:15])([O-])=O.CO.N.[H][H]>[Pd].O>[CH3:15][O:14][C:5]1[CH:6]=[CH:7][C:8]([NH:10][C:11](=[O:13])[CH3:12])=[CH:9][C:4]=1[NH2:1]

Komponenten

7

Edukt 4

HCID 222AmmoniaHCID 887MethanolHCID 95043Acetamide, N-(4-methoxy-3-nitrophenyl)-HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 807793'-Amino-4'-methoxyacetanilide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel2×

Versuchsvorschrift

104 parts of 2-nitro-4-acetamidoanisole, 200 parts of methanol, 1.2 parts of a 30% aqueous solution of ammonia and 2 parts of a 50% suspension of palladium on charcoal, moist with water, in 2 parts of water are charged to an autoclave equipped with an aerating stirrer. The autoclave is pressurised with hydrogen and, at a pressure of 5 bar and a temperature of 100° C., hydrogenation is carried out for 2 hours. 2-Methoxy-5-acetamidoaniline is obtained in quantitative yield in a purity of >97% (analysis by liquid chromatography).

Aufarbeitung

  1. customequipped with an aerating stirrer

Quellen und Nachweise

ORD-Eintrag
ord-55012430aa88442d939a9871a4d0e78b
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05107022

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