HCID 10516623, Verbindung → 2-Benzylthio-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1031352Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1031352
[CH2:1]([S:8][C:9]1[N:18]=[C:12]2[N:13]=[C:14](Cl)[CH:15]=[CH:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][O-:20].[Na+]>CO.O>[CH2:1]([S:8][C:9]1[N:18]=[C:12]2[N:13]=[C:14]([O:20][CH3:19])[CH:15]=[CH:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 10516623HCID 10516623, VerbindungHCID 10942334Sodium Methoxide

Produkt 1

HCID 107546512-Benzylthio-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidineAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 6.0 g (22 mmol) of 2-benzylthio-5-chloro-1,2,4-triazolo[1,5-a]pyrimidine in 25 ml of methanol was treated with 5.0 g (23.8 mmol) of a 25% solution of sodium methoxide in methanol. After stirring for 1.5 hours the reaction mixture was diluted with 100 ml of water and neutralized with 3N HCL (aq). The solid which separated was collected by filtration, washed with water and dried to afford 5.0 g (84%) of the desired product as a white solid, m.p. 126°-128° C. IR and 1H NMR spectra were in agreement with the assigned structure.

Aufarbeitung

  1. customThe solid which separated
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f423734295f74971b92c627570cc40ce
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04954163

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