Ammonium Hydroxide → HCID 15053448, Verbindung

HRID 1032144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032144
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[OH-].[NH4+:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH2:17])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 14923Ammonium HydroxideHCID 15042229HCID 15042229, Verbindung

Produkt 1

HCID 15053448HCID 15053448, VerbindungAusbeute 52,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 5 g (0.02 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred while 4 ml (0.06 mole) of 57% ammonium hydroxide was added all at once. After stirring for 18 hr, the reaction mixture was diluted with 200 ml of water and the solid which separated was collected by filtration, 10.5 g. Recrystallization from isopropanol yielded 2.4 g (52.9%) of gray crystalline powder, m.p. 187°-188° C.

Aufarbeitung

  1. additionwas added all at once
  2. customthe solid which separated
  3. filtrationwas collected by filtration, 10.5 g
  4. customRecrystallization from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-9a52b2f9cdf34a9f8f6bbf6e34644b2e
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04956359

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