Water → 1-Azido-3-acetoxyacetone

HRID 1032358

Reaktionsgleichung

Reaktionsgleichung von HRID 1032358
Cl[CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4].O.[N-:11]=[N+:12]=[N-:13].[Na+]>O1CCCC1.CCOCC>[N:11]([CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4])=[N+:12]=[N-:13]

Komponenten

6

Edukt 3

HCID 962WaterHCID 33557Sodium AzideHCID 384132-Propanone, 1-(acetyloxy)-3-chloro-

Produkt 1

HCID 144347801-Azido-3-acetoxyacetone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1-Chloro-3-acetoxyacetone (15.05 g.) is dissolved in tetrahydrofuran (50 ml.) and water (25 ml.) is added. Sodium azide (8.7 g.) is added and the mixture is allowed to stir overnight at room temperature. The reaction mixture is diluted with ether (200 ml.) and the aqueous phase is separated. The organic phase is washed once with brine, then dried and evaporated to give 1-azido-3-acetoxyacetone.

Aufarbeitung

  1. customthe aqueous phase is separated
  2. washThe organic phase is washed once with brine
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-961487a4299a4276a608f00d388e8d21
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04957912

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