Triethylamine → N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide

HRID 1032539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032539
C(N(CC)CC)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])=[CH:11][C:10]=1[O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:32](Cl)(=[O:36])[CH2:33][CH2:34][CH3:35]>O1CCCC1.O>[CH2:25]([O:24][C:10]1[CH:11]=[C:12]([CH2:15][CH2:16][N:17]([CH2:18][CH2:19][CH3:20])[CH2:21][CH2:22][CH3:23])[CH:13]=[CH:14][C:9]=1[NH:8][C:32](=[O:36])[CH2:33][CH2:34][CH3:35])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 22165977HCID 22165977, Verbindung

Produkt 1

HCID 22166027N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.3 ml of triethylamine is added to 0.65 g of N-[2-(4-amino-3-benzyloxyphenyl)ethyl]-N,N-dipropylamine in 10 ml of tetrahydrofuran, and then 0.23 ml of butyryl chloride is added dropwise thereto. The reaction mixture is stirred for one hour at room temperature, diluted with water, and the product extracted by shaking with methylene chloride, isolating 770 mg of N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide as an oil from the methylene chloride solution.

Aufarbeitung

  1. extractionthe product extracted
  2. stirringby shaking with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-4356bc771a284de6a5842a169bffc404
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04958026

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