Dichloromethane → 1-Methoxy-4-methyl-2-nitrobenzene

HRID 1032960

Reaktionsgleichung

Reaktionsgleichung von HRID 1032960
[N+:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([CH3:11])[CH:5]=1)([O-:3])=[O:2].[CH2:12](Cl)Cl.[OH-].[Na+].S(OC)(OC)(=O)=O>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH3:11][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH3:12])=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Komponenten

7

Edukt 4

HCID 6344DichloromethaneHCID 6497Dimethyl SulfateHCID 83914-Methyl-2-nitrophenolHCID 14798Sodium Hydroxide

Produkt 1

HCID 670581-Methoxy-4-methyl-2-nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

A reaction mixture of 2-nitro-p-cresol (23.58 g, 0.154 mmol), methylene chloride (200 ml), tetra-n-butylammonium hydrogensulfate (5.15 g, 15.2 mmol), 1N sodium hydroxide (170 ml) and dimethyl sulfate (16.0 ml, 0.169 mmol) was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted with methylene chloride. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated. The concentrate was immediately used for the next reaction.

Aufarbeitung

  1. extractionextracted with methylene chloride
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated
  5. customThe concentrate was immediately used for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-094d3f7d7ae542c3b24245f12e026bc1
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05308840

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