Acetone → {[(2-Methyl-1-nitropropan-2-yl)sulfanyl]methyl}benzene

HRID 1033822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1033822
[CH3:1][C:2]([CH3:4])=O.[CH2:5]([SH:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[N+:13]([CH3:16])([O-:15])=[O:14].N1CCCCC1>C1C=CC=CC=1.O>[CH2:5]([S:12][C:2]([CH3:4])([CH3:1])[CH2:16][N+:13]([O-:15])=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

7

Edukt 4

HCID 180AcetoneHCID 6375NitromethaneHCID 7509Benzyl mercaptanHCID 8082Piperidine

Produkt 1

HCID 14613816{[(2-Methyl-1-nitropropan-2-yl)sulfanyl]methyl}benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241BenzeneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Acetone (25 g), benzyl mercaptan (53 g), nitromethane (26.2 g), and piperidine (8 cm3) were dissolved in benzene (150 cm3) and the mixture heated under reflux with azeotropic removal of water. After 48 h the reaction mixture was allowed to cool and washed first with dilute hydrochloric acid, then with water. The remaining solution was dried (MgSO4) and the solvent then removed under reduced pressure to give the nitro system (76.5 g, 85%). This material was sufficiently pure to be used without further purification.

Aufarbeitung

  1. temperaturethe mixture heated
  2. temperatureto cool
  3. washwashed first with dilute hydrochloric acid
  4. dry with materialThe remaining solution was dried (MgSO4)
  5. customthe solvent then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f1507ad9f5b4440ba0987a3e0f60a33b
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05312904

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