Water → 5-Phenyl-2-trityltetrazole

HRID 1034455

Reaktionsgleichung

Reaktionsgleichung von HRID 1034455
[C:1]1([C:7]2[NH:11][N:10]=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:19]1([C:25](Cl)([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O.O1CCCC1>[C:1]1([C:7]2[N:8]=[N:9][N:10]([C:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 6456Trityl chlorideHCID 8471TriethylamineHCID 178418369HCID 178418369, Verbindung

Produkt 1

HCID 32929595-Phenyl-2-trityltetrazoleAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 5.0 g (34.2 mmol) of 5-phenyltetrazole in 55 mL of acetone was added 5.0 mL of triethylamine (3.6g, 35.6 mmol, 1.04eq). After 15 minutes, a solution of 10.0 g of triphenylmethyl chloride (35.9 mmol, 1.05eq) in 20 mL of tetrahydrofuran was added and the mixture stirred at room temperature for one hour. Water (75 mi) was slowly added and the mixture stirred for one hour at room temperature. The product was collected by filtration, washed with 75 mL of water and dried at 60° C. under vacuum to give 13.3g (34.2 mmol, 100%) of the product.

Aufarbeitung

  1. stirringthe mixture stirred for one hour at room temperature
  2. filtrationThe product was collected by filtration
  3. washwashed with 75 mL of water
  4. customdried at 60° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0adf00e32c74443a8338eb19a9bb7a0c
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05317017

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