Water → HCID 178447445, Verbindung

HRID 1036525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036525
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]([N+:29]([O-:31])=[O:30])([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([C:25]([F:28])([F:27])[F:26])[CH2:21][CH2:20]3)[CH:14]=2)[CH:9]=1)[CH3:7].[OH-].[Li+].O>CO.O1CCCC1>[N+:29]([C:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([C:25]([F:26])([F:27])[F:28])[CH2:23][CH2:24]3)[CH:14]=2)[CH:9]=1)([CH3:7])[CH2:5][CH2:4][C:3]([OH:32])=[O:2])([O-:31])=[O:30]

Komponenten

6

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 178500165HCID 178500165, Verbindung

Produkt 1

HCID 178447445HCID 178447445, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-nitro-4-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid methyl ester (0.098 g, 0.22 mmol) in methanol (1.00 mL, Fisher) and tetrahydrofuran (1.00 mL, Acros) was added 2 M lithium hydroxide in water (1.00 mL, 2.00 mmol). The mixture was stirred at room temperature. After 2 hours, the mixture was concentrated under vacuum. The resulting product was diluted in methylene chloride and washed with 1N HCl. The combined organic phases were dried over Na2SO4, filtered and concentrated to give the product in 99 mg yield (100%).

Aufarbeitung

  1. concentrationthe mixture was concentrated under vacuum
  2. additionThe resulting product was diluted in methylene chloride
  3. washwashed with 1N HCl
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give the product in 99 mg
  8. customyield (100%)

Quellen und Nachweise

ORD-Eintrag
ord-105b11e2eba840828d998e7fba17b2cb
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546359B2

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