1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 178502733, Verbindung

HRID 1036534Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036534
[OH:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.CCN=C=NCCCN(C)C.CCN(C(C)C)C(C)C.Cl.[CH3:32][NH:33][O:34][CH3:35]>C(Cl)Cl.O>[OH:1][C@@H:2]1[CH2:3][CH2:4][C@H:5]([C:8]([N:33]([O:34][CH3:35])[CH3:32])=[O:10])[CH2:6][CH2:7]1

Komponenten

7

Edukt 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 81531DiisopropylethylamineHCID 178525779HCID 178525779, Verbindung

Produkt 1

HCID 178502733HCID 178502733, VerbindungAusbeute 46,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Cis-4-hydroxycyclohexanecarboxylic acid (6 g, 0.042 mol) and EDCI (9.6 g, 0.05 mol, 1.2 eq.) were dissolved in DCM (100 mL) at 0° C. and stirred for 10 min. DIPEA (16 mL, 0.126 mol, 3.0 eq.) and N,O-dimethylhydroxylamine hydrochloride (4.44 g, 0.046 mol, 1.1 eq.) were added to the mixture at 0° C. The mixture was warmed to room temperature and stirred for 15 h., water was added and the mixture was extracted with DCM. The organic layer was concentrated and purified by silica gel column chromatography using DCM/CH3OH (10/1) to give product as a colorless oil (3.685 g, 40%). 1H NMR (400 MHz, CDCl3) δ: 4.01 (s, 1H), 3.70 (s, 3H), 3.18 (s, 3H), 2.72-2.69 (m, 1H), 1.98-1.85 (m, 4H), 1.62-1.55 (m, 4H).

Aufarbeitung

  1. stirringstirred for 15 h.
  2. extractionthe mixture was extracted with DCM
  3. concentrationThe organic layer was concentrated
  4. custompurified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2b1a728a7aa64d6aa9ea183c5a078ecd
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546359B2

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