Bromine → 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine

HRID 1038121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1038121
[N:1]1([C:6]2[N:11]=[CH:10][CH:9]=[CH:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Br:12]Br>C(O)(=O)C>[Br:12][C:4]1[CH:3]=[N:2][N:1]([C:6]2[N:7]=[CH:8][CH:9]=[CH:10][N:11]=2)[CH:5]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 111707712-(1H-Pyrazol-1-yl)pyrimidine

Produkt 1

HCID 457897012-(4-Bromo-1H-pyrazol-1-yl)pyrimidineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

To a solution of 2-pyrazol-1-yl-pyrimidine (0.55 g, 3.7 mmol) in acetic acid (5 mL) was added bromine (1.2 g, 7.5 mmol) in acetic acid (3 mL) dropwisely. After addition, the reaction mixture was stirred at room temperature overnight. After removed the acetic acid, the crude product was purified using column chromatography (2% methanol in dichloromethane) to give 0.7 g of pure product in 85% yield. MS (ESMS, M+H 225).

Aufarbeitung

  1. additionAfter addition
  2. customAfter removed the acetic acid
  3. customthe crude product was purified

Quellen und Nachweise

ORD-Eintrag
ord-19f31f338b3a44819c22eb0230e11faa
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546404B2

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