Cesium carbonate → methyl(1S,4R)-4-{5-[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-nitrophenyl]-1,3-thiazol-2-yl}-4-hydroxy-2,2-dimethylcyclohexanecarboxylate

HRID 1039947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1039947
[C:1]([Si:5]([CH3:27])([CH3:26])[O:6][CH2:7][C:8]1[CH:13]=[C:12](B2OC(C)(C)C(C)(C)O2)[CH:11]=[C:10]([N+:23]([O-:25])=[O:24])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:29]1[S:33][C:32]([C@@:34]2([OH:46])[CH2:39][CH2:38][C@H:37]([C:40]([O:42][CH3:43])=[O:41])[C:36]([CH3:45])([CH3:44])[CH2:35]2)=[N:31][CH:30]=1.C(=O)([O-])[O-].[Cs+].[Cs+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1>O1CCOCC1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Si:5]([O:6][CH2:7][C:8]1[CH:13]=[C:12]([C:29]2[S:33][C:32]([C@@:34]3([OH:46])[CH2:39][CH2:38][C@H:37]([C:40]([O:42][CH3:43])=[O:41])[C:36]([CH3:44])([CH3:45])[CH2:35]3)=[N:31][CH:30]=2)[CH:11]=[C:10]([N+:23]([O-:25])=[O:24])[CH:9]=1)([C:1]([CH3:2])([CH3:3])[CH3:4])([CH3:26])[CH3:27]

Komponenten

8

Edukt 4

HCID 10796Cesium carbonateHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 58456350(1S,4R)-4-(5-Bromo-thiazol-2-yl)-4-hydroxy-2,2-dimethyl-cyclohexanecarboxylic acid methyl esterHCID 67433819Tert-butyl(dimethyl){[3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]oxy}silane

Produkt 1

HCID 67432153methyl(1S,4R)-4-{5-[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-nitrophenyl]-1,3-thiazol-2-yl}-4-hydroxy-2,2-dimethylcyclohexanecarboxylateAusbeute 54.305,602 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a stirring solution of the product of Step 2 (7.91 g, 20.1 mmol) in dioxane (30 mL) and water (4 mL) was added methyl(1S,4R)-4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxy-2,2-dimethylcyclohexanecarboxylate (5 g, 14.4 mmol) and cesium carbonate (14 g, 43.1 mmol). The solution was deoxygenated, then tris(dibenzylideneacetone)dipalladium(0) (0.66 g, 0.72 mmol) and 2-(dicyclohexylphosphino)-2′,4′,6′-triisopropylbiphenyl (0.68 g, 1.44 mmol) were added and the mixture was stirred at 100° C. for 15 h. The mixture was cooled to room temperature and quenched with 1:1 saturated aqueous sodium bicarbonate:brine. The mixture was extracted with ethyl acetate, and the organic layer was dried over sodium sulfate, filtered, and concentrated. Purification by flash chromatography on silica gel (0-50% ethyl acetate in hexanes) afforded methyl(1S,4R)-4-{5-[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-nitrophenyl]-1,3-thiazol-2-yl}-4-hydroxy-2,2-dimethylcyclohexanecarboxylate (4.4 g, 7.82 mol, 54% yield) as an orange oil. MS ESI: [M+H]+ m/z 535.2.

Aufarbeitung

  1. customThe solution was deoxygenated
  2. temperatureThe mixture was cooled to room temperature
  3. customquenched with 1:1 saturated aqueous sodium bicarbonate
  4. extractionThe mixture was extracted with ethyl acetate
  5. dry with materialthe organic layer was dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customPurification by flash chromatography on silica gel (0-50% ethyl acetate in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-a6eff2aaee2546b0b2da494a56ab7d84
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08551984B2

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