Triethylamine → HCID 86669120, Verbindung

HRID 1041830

Reaktionsgleichung

Reaktionsgleichung von HRID 1041830
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](O)=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1.C(N(CC)CC)C.[F:22][C:23]([F:36])([F:35])[S:24]([O:27]S(C(F)(F)F)(=O)=O)(=[O:26])=[O:25]>CN(C)C1C=CN=CC=1.ClCCl>[F:22][C:23]([F:36])([F:35])[S:24]([OH:27])(=[O:26])=[O:25].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 831204-Chloro-2-cyclohexylphenol

Produkt 1

HCID 86669120HCID 86669120, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-5 °C

Versuchsvorschrift

19 g (90.2 mmol) of 4-chloro-2-cyclohexylphenol, 4.64 ml (33.18 mmol) of triethylamine and 223 mg (1.8 mmol) of 4-(dimethylamino)pyridine are dissolved in 264 ml of dichloromethane, the mixture is cooled to −5° C., and 29.6 ml (180 mmol) of trifluoromethanesulfonic anhydride are added dropwise. The batch is stirred overnight at room temperature and filtered through silica gel with dichloromethane, giving the product 7, which is employed in the next step without further purification.

Aufarbeitung

  1. filtrationfiltered through silica gel with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-55f07e4467df4f35a9840a534c5bfa5b
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08557142B2

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