Lithium Hydroxide → 3-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid

HRID 1042470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1042470
C[O:2][C:3](=[O:19])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:7]=1[CH2:16][CH2:17][CH3:18].[Li+].[OH-]>C1COCC1.O>[CH2:16]([C:7]1[CH:8]=[C:9]([C:12]([F:13])([F:15])[F:14])[CH:10]=[CH:11][C:6]=1[CH:5]=[CH:4][C:3]([OH:19])=[O:2])[CH2:17][CH3:18]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 668554943-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester

Produkt 1

HCID 668558853-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acidAusbeute 74,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 3-(2-propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester (220 mg, 0.81 mmol) in THF (3 mL) was added a solution of 1N-LiOH (6 ml), and the mixture was stirred for 3 hours at room temperature. The reaction mixture was diluted with H2O, which was washed three times with EtOAc, acidified with 1N HCl to pH 1-2. The resulting solution was extracted three times with methylene chloride and then dried over anhydrous MgSO4 and concentrated in vacuo to give the title compound (155 mg, 74%).

Aufarbeitung

  1. washwas washed three times with EtOAc
  2. extractionThe resulting solution was extracted three times with methylene chloride
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0412593cba6d4241acb54ea9dce995d6
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08557872B2

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