2-(Dimethylamino)ethanol → 2-(2-Dimethylaminoethoxy)-5-nitropyridine

HRID 1043771Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1043771
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][OH:5].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].Cl[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][N:19]=1>CN(C=O)C.O.CCOC(C)=O>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([O:5][CH2:4][CH2:3][N:2]([CH3:6])[CH3:1])=[N:19][CH:20]=1)([O-:26])=[O:25]

Komponenten

7

Edukt 3

HCID 79022-(Dimethylamino)ethanolHCID 783082-Chloro-5-nitropyridineHCID 2724254Sodium bis(trimethylsilyl)amide

Produkt 1

HCID 529049082-(2-Dimethylaminoethoxy)-5-nitropyridineAusbeute 44,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2-(dimethylamino)ethanol (339 mg, 3.80 mmol) in DMF (5 mL) was added sodium bis(trimethylsilyl)amide (4.75 mL, 1M solution in THF, 4.75 mmol). The mixture was stirred at room temperature for 15 min. 2-Chloro-5-nitropyridine (500 mg, 3.16 mmol) was then added. The vial was capped and subjected to microwave irradiation (150° C. for 10 minutes). The mixture was diluted with water (250 mL) and EtOAc (250 mL). The two layers were separated, and the aqueous layer extracted two more times with EtOAc. The organic extracts were combined, washed with water and brine, dried over sodium sulfate and evaporated to give the crude material as brown oil. Purification by column chromatography on silica gel using 5% methanol/methylene chloride yielded 2-(5-nitropyridin-2-yloxy)-N,N-dimethylethanamine as a light yellow solid (295 mg, 44%).

Aufarbeitung

  1. customThe vial was capped
  2. customsubjected to microwave irradiation (150° C. for 10 minutes)
  3. customThe two layers were separated
  4. extractionthe aqueous layer extracted two more times with EtOAc
  5. washwashed with water and brine
  6. dry with materialdried over sodium sulfate
  7. customevaporated
  8. customto give the crude material as brown oil
  9. customPurification by column chromatography on silica gel using 5% methanol/methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-b1023bc0c99c41a5b0ad6053d5572e25
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563549B2

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