Dimethylformamide → 3-Bromo-5-fluoro-2-methoxy-4-methylpyridine

HRID 1043919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1043919
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8].CN([CH:14]=[O:15])C.C[O-].[Na+]>O>[Br:1][C:2]1[C:3]([O:15][CH3:14])=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 10942334Sodium MethoxideHCID 73555087HCID 73555087, Verbindung

Produkt 1

HCID 866863433-Bromo-5-fluoro-2-methoxy-4-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

3-bromo-2-chloro-5-fluoro-4-methylpyridine (340 mg) was added to DMF (1.8 mL). Sodium methoxide (28% solution in methanol, 5.4 mL) was added to the solution, and the mixture was stirred at 80° C. for two hours. Water was added to the reaction mixture. The precipitated solid was collected by filtration to give the title compound (240 mg).

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ad0a96bf3f0247ac90b793971266620f
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563565B2

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