Methyl 4-Formylbenzoate → Methyl 4-[(R)-1-[(2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl]-1-(3-tert-butyldimethylsilyloxyphenyl)methyl]benzoate

Temperatur

-17.5 °C

A solution of (−)-(2R,5S)-1-allyl-2,5-dimethylpiperazine (22.26 g), benzotriazole (17.18 g) and methyl 4-formylbenzoate (23.7 g) in toluene (400 ml) was heated under reflux with azeotropic removal of water for 3 hours. The solution was cooled and added to a cold solution (−20° C.) of 3-tert-butyldimethylsilyloxyphenylmagnesium bromide (prepared from 82.9 g of corresponding bromide and 7.29 g of magnesium turnings) in tetrahydrofuran (300 ml) at such a rate as to maintain the internal temperature in the range −20 to −15° C. The resulting solution was stirred at −20° C. for 1.5 hours and then warmed to room temperature, quenched with saturated aqueous ammonium chloride solution (200 ml). The layers were separated and the aqueous solution extracted with ethyl acetate (2×200 ml). The combined organic extracts were dried (MgSO4) and evaporated to dryness in vacuo. The residue was purified by column chromatography over silica gel (85/15/2 hexane/ethyl acetate/diethyl amine) to afford the title compound, 54.45 g.

1. temperatureThe solution was cooled
2. temperaturewarmed to room temperature
3. customquenched with saturated aqueous ammonium chloride solution (200 ml)
4. customThe layers were separated
5. extractionthe aqueous solution extracted with ethyl acetate (2×200 ml)
6. dry with materialThe combined organic extracts were dried (MgSO4)
7. customevaporated to dryness in vacuo
8. customThe residue was purified by column chromatography over silica gel (85/15/2 hexane/ethyl acetate/diethyl amine)

ORD-Eintrag

ord-ebd0c3692d3646278f632ab9c539bd39

Quelldatensatz

uspto-grants-2003_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06514975B1