Ethyl Acetate → 2-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromide

HRID 1062624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1062624
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Br:18]Br.C(OCC)(=O)C>C(O)(=O)C>[BrH:18].[Br:18][CH:10]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[C:9]([C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:17]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 24408BromineHCID 222822971-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone

Produkt 1

HCID 222823612-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromideAusbeute 268,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

1-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone (7.0 g, 31 mmol) was dissolved in acetic acid (35 mL) and bromine (1.6 mL, 31 mmol) was added. The mixture was stirred at 80° C. for 3 h. Ethyl acetate was added to the residue and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (16 g, yield 96%).

Aufarbeitung

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-6f7af2f2688c4bf982c5924a2bc5786b
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06962933B1

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