Ammonia → 1-(4-Methoxybenzo[d]thiazol-2-yl)urea

HRID 1063009

Reaktionsgleichung

Reaktionsgleichung von HRID 1063009
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[NH2:13][C:14](N)=[O:15].N>O>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:14]([NH2:13])=[O:15])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 1176UreaHCID 216224-Methoxy-2-aminobenzothiazole

Produkt 1

HCID 222830361-(4-Methoxybenzo[d]thiazol-2-yl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-4-methoxy-benzothiazole (330 mg, 1.83 mmol) and urea (1.1 g, 1.83 mmol) were heated together for 1 h at 170° C., with evolution of ammonia. After allowing to cool to r.t., water (10 ml) was added and the mixture was vigorously stirred. The solid was then filtered, washed with water (10 ml) followed by ethanol (10 ml) and dried at 60° C. under vaccum (0.05 mmHg). The title product was afforded as an off-white solid (300 mg, 73% yield), MS: m/e=223 (M+).

Aufarbeitung

  1. filtrationThe solid was then filtered
  2. washwashed with water (10 ml)
  3. customdried at 60° C. under vaccum (0.05 mmHg)

Quellen und Nachweise

ORD-Eintrag
ord-a9d58f8a0f5941698af175583e3b939a
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06963000B2

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