Pyridine → HCID 69355802, Verbindung

HRID 1064080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1064080
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1.[C:21]([O:24]C(=O)C)(=[O:23])C.N1C=CC=CC=1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:19][C:16]2[CH:15]=[CH:14][N:13]=[CH:18][CH:17]=2)[C:10](=[O:12])[C:21]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

7

Edukt 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 133894-PyridinecarboxaldehydeHCID 798743,4-Dichlorophenylacetic acid

Produkt 1

HCID 69355802HCID 69355802, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To mixture of (3,4-diChloro-phenyl)-acetic acid 10.3 g and pyridine-4-carbaldehyde 5.25 mL was added acetic anhydride 6 mL and pyridine 6 mL. The reaction mixture was heated to 120° C. for 2 hours and cooled down to room temperature. Water and ethyl acetate were added. The solid formed was filtered, washed with water and ethyl acetate and dried to afford the title compound 10.2 g as a light yellow solid. MS (ES+): 292 (M+H)+.

Aufarbeitung

  1. temperaturecooled down to room temperature
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water and ethyl acetate
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f6a6dd6deb874fbe92a88efe556fddc6
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06967254B2

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