Hydrogen Peroxide → 5-(4-Phenylsulfinyl-butoxy)-carbostyril

HRID 1065371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1065371
[OH:1]O.[C:3]1([S:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.O>[C:3]1([S:9]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)=[O:1])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 538402795-(4-Phenylmercapto-butoxy)-carbostyril

Produkt 1

HCID 205401285-(4-Phenylsulfinyl-butoxy)-carbostyril

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

0.165 ml of 30% hydrogen peroxide, dissolved in 8 ml of glacial acetic acid, were added to 0.56 gm of 5-(4-phenylmercapto-butoxy)-carbostyril. The mixture was diluted with water and extracted twice with chloroform. The chloroform extract was washed with dilute sodium carbonate solution and with water, dried over magnesium sulfate and evaporated. The residue was admixed with ethyl acetate, yielding colorless crystals with a melting point of 155°-157° C.

Aufarbeitung

  1. extractionextracted twice with chloroform
  2. extractionThe chloroform extract
  3. washwas washed with dilute sodium carbonate solution and with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customyielding colorless crystals with a melting point of 155°-157° C.

Quellen und Nachweise

ORD-Eintrag
ord-6e5d00fc9ec0487eaf7db48c123f4ebf
Quelldatensatz
uspto-grants-1982_05
Patentnummer
US04329347

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