Formaldehyde → 2-(1-Methylpiperidin-4-yl)acetic acid

HRID 1066312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066312
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.[CH2:11]=O>O.[Pd]>[CH3:11][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 712FormaldehydeHCID 15125944-Piperidineacetic acid

Produkt 1

HCID 4286192-(1-Methylpiperidin-4-yl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

4-Piperidinylacetic acid (4 grams) (28.0 mmoles) from Preparative Example 17A was dissolved in water (50 ml) and 37% formalin (2.72 ml) (33.6 mmoles) was added. The mixture was hydrogenated over 10% Pd—C at 55 psi at 25° C. for 68 hours. The catalyst was filtered off and washed with water. The combined filtrates were evaporated to dryness to give the title compound (MH+158).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with water
  3. customThe combined filtrates were evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-3e94823dbe154ba7bda28806e5c7382c
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242458B1

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