Hydrochloric Acid → (5-(1-Hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide

HRID 1066505

Reaktionsgleichung

Reaktionsgleichung von HRID 1066505
[K+].[CH:2]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH-:14])(=[O:13])=[O:12])=[N:9][CH:10]=1)([CH3:4])[CH3:3].[O-:15][Mn](=O)(=O)=O.[K+].Cl>O>[OH:15][C:2]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH2:14])(=[O:13])=[O:12])=[N:9][CH:10]=1)([CH3:4])[CH3:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 516875Potassium PermanganateHCID 1317209445-Isopropyl pyridine-2-sulfonamide potassium salt

Produkt 1

HCID 54360667(5-(1-Hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 5-isopropyl-pyridine-2-sulfonamide potassium salt (synthesis described in EP 0 799 209) in water (10 ml) were added 1.2 g of KMnO4 at RT and the mixture was then refluxed for 30 minutes. The mixture was cooled to RT, acidified with diluted HCl and the product was extracted into AcOEt. The organic layer was washed with washed with water, dried over Na2SO4 and concentrated in vacuo to give (5-(1-hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide as yellow oil. EI mass spectrum, m/e 216 (M calculated for: C8H12N2O3S 216).

Aufarbeitung

  1. temperaturethe mixture was then refluxed for 30 minutes
  2. extractionthe product was extracted into AcOEt
  3. washThe organic layer was washed
  4. washwith washed with water
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c31ba97edaf847d8a81e22851e037264
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242601B1

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