Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 1066646Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066646
[Br:1]Br.[BrH:3].[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:3][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 212004624-Acetyl-4-phenylpiperidine hydrobromide

Produkt 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromideAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

7.9 g of bromine are added rapidly at RT to a suspension of 14 g of 4-acetyl-4-phenylpiperidine hydrobromide in 200 ml of DCM and the reaction mixture is stirred overnight at RT. It is diluted by the addition of 200 ml of ether and the precipitate formed is wrung and washed with ether to give 16.7 g of the expected product after drying under vacuum.

Aufarbeitung

  1. customthe precipitate formed
  2. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-e00921bfd75e4c38a3e801d76412bc7d
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242637B1

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