Carbon tetrabromide → HCID 21196139, Verbindung

HRID 1066829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066829
[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:36]>C(OCC)C>[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:36]

Komponenten

5

Edukt 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 211961624-(2-Fluoro-5-bromobenzyloxy)butanol

Produkt 1

HCID 21196139HCID 21196139, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 4-(2-fluoro-5-bromobenzyloxy)butanol (7.03 g, 26.3 mmol) in diethyl ether (88 ml) was treated with triphenylphosphine (8.97 g, 34.2 mmol) and carbon tetrabromide (11.3 g, 34.2 mmol). The cloudy solution was stirred at ambient temperature for about 30 hours. The precipitate was removed by filtration and the filtrate was concentrated. The desired title intermediate was purified from the filtrate by bulb to bulb distillation.

Aufarbeitung

  1. customThe precipitate was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. distillationThe desired title intermediate was purified from the filtrate by bulb to bulb distillation

Quellen und Nachweise

ORD-Eintrag
ord-08bfffead2d44ba6b108f68f28ad0cfc
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06245761B1

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