Cl.Cl.[F:3][C:4]1[CH:5]=[C:6]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[F:10].C(N(C(C)C)CC)(C)C.[Cl:28][CH2:29][C:30](Cl)=[O:31].O>O1CCCC1.[Cl-].[Na+].O.C(OCC)(=O)C>[Cl:28][CH2:29][C:30]([NH:18][CH:15]1[CH2:16][CH2:17][N:12]([CH2:11][C:6]2[CH:7]=[CH:8][C:9]([F:10])=[C:4]([F:3])[CH:5]=2)[CH2:13][CH2:14]1)=[O:31]1-[(3,4-Difluorophenyl)methyl]-piperidin-4-ylamine dihydrochloride (3.18 g) was dissolved in tetrahydrofuran (40 ml). Diisopropylethlamine (6.84 g) and chloroacetyl chloride (1.33 g) were added. After 3 hours water, brine and ethyl acetate were added the phase were separated. The organic phase was dried, filtered and evaporated and the residue was purified by chromatography eluting with ethyl acetate to give the subtitle compound (0.728 g).
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